4DHF.A | AURKA

General Structure Information 4dhf AURKA structure of aurora a mutant bound to biogenidec cpd 15 2.8Å AUTH J.Y.LE BRAZIDEC,A.PASIS,B.TAM,C.BOYKIN,D.WANG,D.J.MARCOTTE,AUTH 2 G.CLAASSEN,J.H.CHONG,J.CHAO,J.FAN,K.NGUYEN,L.SILVIAN,L.LING,AUTH 3 L.ZHANG,M.CHOI,M.TENG,N.PATHAN,S.ZHAO,T.LI,A.TAVERASTITL STRUCTURE-BASED DESIGN OFTITL 2 2,6,7-TRISUBSTITUTED-7H-PYRROLO[2,3-D]PYRIMIDINES AS AURORATITL 3 KINASES INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 4033 2012REFN ISSN 0960-894XPMID 22607669DOI 10.1016/J.BMCL.2012.04.085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]

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3OL2.B | PLXNB1

General Structure Information 3ol2 PLXNB1 receptor-ligand structure of human semaphorin 4d with plexin b1. 2.99Å AUTH B.J.JANSSEN,R.A.ROBINSON,F.PEREZ-BRANGULI,C.H.BELL,AUTH 2 K.J.MITCHELL,C.SIEBOLD,E.Y.JONESTITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN SIGNALLING.REF NATURE V. 467 1118 2010REFN ISSN 0028-0836PMID 20877282DOI 10.1038/NATURE09468 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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1WX6.A | NCK2

General Structure Information 1wx6 NCK2 solution structure of the sh3 domain of the human cytoplasmic protein nck2 -1.0Å AUTH S.OHNISHI,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 CYTOPLASMIC PROTEIN NCK2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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4GMJ.C | CNOT1

General Structure Information 4gmj CNOT1 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]

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2P0R.B | CAPN9

General Structure Information 2p0r CAPN9 structure of human calpain 9 in complex with leupeptin 2.5Å AUTH T.L.DAVIS,R.PARAMANATHAN,J.R.WALKER,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURES OF HUMAN MINICALPAINS BOUND TO INHIBITORSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4NPJ.A | ESYT2

General Structure Information 4npj ESYT2 extended-synaptotagmin 2, c2a- and c2b-domains 2.1Å AUTH J.XU,T.BACAJ,A.ZHOU,D.R.TOMCHICK,T.C.SUDHOF,J.RIZOTITL STRUCTURE AND CA(2+)-BINDING PROPERTIES OF THE TANDEM C2TITL 2 DOMAINS OF E-SYT2.REF STRUCTURE V. 22 269 2014REFN ISSN 0969-2126PMID 24373768DOI 10.1016/J.STR.2013.11.011 Variant Set Distributions Mapped Variants

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2CSI.A | RIMBP2

General Structure Information 2csi RIMBP2 solution structure of the third sh3 domain of human rim- binding protein 2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD SH3 DOMAIN OFTITL 2 HUMAN RIM-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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3SL9.F | BCL9

General Structure Information 3sl9 BCL9 x-ray structure of beta catenin in complex with bcl9 2.2Å AUTH M.DE LA ROCHE,T.J.RUTHERFORD,D.GUPTA,D.B.VEPRINTSEV,B.SAXTY,AUTH 2 S.M.FREUND,M.BIENZTITL AN INTRINSICALLY LABILE ALPHA-HELIX ABUTTING THETITL 2 BCL9-BINDING SITE OF BETA-CATENIN IS REQUIRED FOR ITSTITL 3 INHIBITION BY CARNOSIC ACID.REF NAT COMMUN V. 3 680 2012REFN ESSN 2041-1723PMID 22353711DOI 10.1038/NCOMMS1680 Variant Set Distributions Mapped […]

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3DXC.A | APBB1

General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants

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2P6V.A | TAF4

General Structure Information 2p6v TAF4 structure of tafh domain of the human taf4 subunit of tfiid 2.0Å AUTH X.WANG,D.M.TRUCKSES,S.TAKADA,T.MATSUMURA,N.TANESE,AUTH 2 R.H.JACOBSONTITL CONSERVED REGION I OF HUMAN COACTIVATOR TAF4 BINDSTITL 2 TO A SHORT HYDROPHOBIC MOTIF PRESENT INTITL 3 TRANSCRIPTIONAL REGULATORS.REF PROC.NATL.ACAD.SCI.USA V. 104 7839 2007REFN ISSN 0027-8424PMID 17483474DOI 10.1073/PNAS.0608570104 Variant Set Distributions Mapped Variants

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