Assessment of Structural Intolerance and Durability
General Structure Information 2gd7 HEXIM1 the structure of the cyclin t-binding domain of hexim1 reveals the molecular basis for regulation of transcription elongation -1.0Å AUTH S.A.DAMES,A.SCHONICHEN,A.SCHULTE,M.BARBORIC,AUTH 2 B.M.PETERLIN,S.GRZESIEK,M.GEYERTITL STRUCTURE OF THE CYCLIN T BINDING DOMAIN OF HEXIM1TITL 2 AND MOLECULAR BASIS FOR ITS RECOGNITION OF P-TEFB.REF PROC.NATL.ACAD.SCI.USA V. 104 14312 2007REFN ISSN 0027-8424PMID 17724342DOI 10.1073/PNAS.0701848104 […]
General Structure Information 2ezy BANF1 solution structure of human barrier-to-autointegration factor baf, nmr, ensemble of 20 simulated annealing structures -1.0Å AUTH M.CAI,Y.HUANG,R.ZHENG,S.Q.WEI,R.GHIRLANDO,M.S.LEE,AUTH 2 R.CRAIGIE,A.M.GRONENBORN,G.M.CLORETITL SOLUTION STRUCTURE OF THE CELLULAR FACTOR BAFTITL 2 RESPONSIBLE FOR PROTECTING RETROVIRAL DNA FROMTITL 3 AUTOINTEGRATION.REF NAT.STRUCT.BIOL. V. 5 903 1998REFN ISSN 1072-8368PMID 9783751DOI 10.1038/2345 Variant Set Distributions Mapped Variants
General Structure Information 4aot STK10 crystal structure of human serine threonine kinase-10 (lok) bound to gw830263a 2.33Å AUTH J.M.ELKINS,E.SALAH,M.SZKLARZ,P.CANNING,F.VON DELFT,W.YUE,AUTH 2 Y.LIU,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 (LOK)TITL 2 BOUND TO GW830263AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qg1 MPDZ crystal structure of the 11th pdz domain of mpdz (mupp1) 1.4Å AUTH E.PAPAGRIGORIOU,E.SALAH,C.PHILLIPS,P.SAVITSKY,AUTH 2 P.BOISGUERIN,H.OSCHKINAT,C.GILEADI,X.YANG,AUTH 3 J.M.ELKINS,E.UGOCHUKWU,G.BUNKOCZI,J.UPPENBERG,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZTITL 2 (MUPP1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3si5 BUB1B kinetochore-bubr1 kinase complex 2.2Å AUTH V.M.BOLANOS-GARCIA,T.LISCHETTI,D.MATAK-VINKOVIC,E.COTA,AUTH 2 P.J.SIMPSON,D.Y.CHIRGADZE,D.R.SPRING,C.V.ROBINSON,J.NILSSON,AUTH 3 T.L.BLUNDELLTITL STRUCTURE OF A BLINKIN-BUBR1 COMPLEX REVEALS AN INTERACTIONTITL 2 CRUCIAL FOR KINETOCHORE-MITOTIC CHECKPOINT REGULATION VIA ANTITL 3 UNANTICIPATED BINDING SITE.REF STRUCTURE V. 19 1691 2011REFN ISSN 0969-2126PMID 22000412DOI 10.1016/J.STR.2011.09.017 Variant Set Distributions Mapped Variants
General Structure Information 3t6a BCAR3 structure of the c-terminal domain of bcar3 2.4Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kot GABARAP solution structure of human gaba receptor associated protein gabarap -1.0Å AUTH T.STANGLER,L.M.MAYR,D.WILLBOLDTITL SOLUTION STRUCTURE OF HUMAN GABA(A)TITL 2 RECEPTOR-ASSOCIATED PROTEIN GABARAP: IMPLICATIONSTITL 3 FOR BIOLGOICAL FUNCRION AND ITS REGULATION.REF J.BIOL.CHEM. V. 277 13363 2002REFN ISSN 0021-9258PMID 11875056DOI 10.1074/JBC.C200050200 Variant Set Distributions Mapped Variants
General Structure Information 2di8 FLNB solution structure of the 19th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 19TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4c5w BBOX1 three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 4-(ethyldimethylammonio)butanoate 1.7Å AUTH K.TARS,J.LEITANS,A.KAZAKS,D.ZELENCOVA,E.LIEPINSH,J.KUKA,AUTH 2 M.MAKRECKA,D.LOLA,V.ANDRIANOVS,D.GUSTINA,S.GRINBERGA,AUTH 3 E.LIEPINSH,I.KALVINSH,M.DAMBROVA,E.LOZA,O.PUGOVICSTITL TARGETING CARNITINE BIOSYNTHESIS: DISCOVERY OF NEWTITL 2 INHIBITORS AGAINST GAMMA-BUTYROBETAINE HYDROXYLASE.REF J.MED.CHEM. V. 57 2213 2014REFN ISSN 0022-2623PMID 24571165DOI 10.1021/JM401603E Variant Set Distributions Mapped Variants
General Structure Information 2lvc OBSL1 solution nmr structure of ig like domain (805-892) of obscurin-like protein 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr8578k -1.0Å AUTH S.PULAVARTI,A.ELETSKY,D.K.SUKUMARAN,D.LEE,E.KOHAN,H.JANJUA,AUTH 2 R.XIAO,T.B.ACTON,J.K.EVERETT,K.PEDERSON,J.PRESTEGARD,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF IG LIKE DOMAIN (805-892) OFTITL 2 OBSCURIN-LIKE PROTEIN 1 FROM HOMO SAPIENS, NORTHEASTTITL 3 STRUCTURAL GENOMICS CONSORTIUM […]