2LVC.A | OBSL1

General Structure Information

PDB ID	2lvc
HGNC Gene Label(s)	OBSL1
Structure Name	solution nmr structure of ig like domain (805-892) of obscurin-like protein 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr8578k
Resolution	-1.0Å
Reference	AUTH S.PULAVARTI,A.ELETSKY,D.K.SUKUMARAN,D.LEE,E.KOHAN,H.JANJUA,AUTH 2 R.XIAO,T.B.ACTON,J.K.EVERETT,K.PEDERSON,J.PRESTEGARD,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF IG LIKE DOMAIN (805-892) OFTITL 2 OBSCURIN-LIKE PROTEIN 1 FROM HOMO SAPIENS, NORTHEASTTITL 3 STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR8578K (CASPTITL 4 TARGET)REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	88
Number Of SNVs	30
Number Of Permutations	8525
Optimal Distance Threshold	9.0
K Statistic	0.122
p-value	0.649

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:220428344		P>A	A:3	(-15.02, -12.88, -2.76)
2:220428340		V>A	A:4	(-10.73, -10.01, -2.10)
2:220428341	rs377151839 COSM1016872	V>M	A:4	(-10.73, -10.01, -2.10)
2:220428331		V>A	A:7	(-2.94, -11.76, 3.27)
2:220428322		R>Q	A:10	(-5.49, -8.56, 8.31)
2:220428313		V>E	A:13	(-0.49, 1.10, 8.69)
2:220428307		V>A	A:15	(3.51, 6.01, 8.01)
2:220428308	rs577797633	V>M	A:15	(3.51, 6.01, 8.01)
2:220428304	rs370114224	H>L	A:16	(7.04, 9.92, 11.74)
2:220428299		I>V	A:18	(10.11, 14.28, 8.10)
2:220428290		E>K	A:21	(11.96, 10.91, 5.10)
2:220428283	rs371867822	V>D	A:23	(6.61, 7.02, 2.77)
2:220428284		V>I	A:23	(6.61, 7.02, 2.77)
2:220428268		E>G	A:28	(0.49, -9.16, 0.26)
2:220428251	rs374921331	A>T	A:34	(-7.80, -9.62, -6.63)
2:220428241	rs371714401	R>H	A:37	(-8.43, 0.34, -7.59)
2:220428242		R>C	A:37	(-8.43, 0.34, -7.59)
2:220428223	COSM3938932 COSM3938931	Q>L	A:43	(-7.46, 12.12, -5.69)
2:220428197		V>M	A:52	(6.65, 5.51, -8.70)
2:220428191		E>K	A:54	(6.35, -0.38, -7.82)
2:220428187		N>S	A:55	(2.84, -3.68, -9.76)
2:220428181	rs370980487	G>E	A:57	(1.17, -10.04, -8.50)
2:220428182		G>R	A:57	(1.17, -10.04, -8.50)
2:220428172		R>H	A:60	(-0.71, -3.88, -6.10)
2:220428170	COSM1016869	R>C	A:61	(5.89, -3.03, -3.44)
2:220428157	rs200723165	P>H	A:65	(10.69, 9.46, -3.94)
2:220428155		A>T	A:66	(10.33, 13.24, -1.92)
2:220428136		G>E	A:72	(0.23, 14.14, 4.17)
2:220428137	rs370345307	G>R	A:72	(0.23, 14.14, 4.17)
2:220428119	COSM3838679 COSM3838678	V>I	A:78	(-9.93, -0.33, -2.41)
2:220428116		A>T	A:79	(-9.22, -5.18, -2.67)
2:220428110		D>N	A:81	(-14.80, -7.15, -0.44)
2:220428104		C>R	A:83	(-10.05, -1.75, 2.39)
2:220428100		A>G	A:84	(-5.79, -1.70, 4.16)
2:220428101		A>T	A:84	(-5.79, -1.70, 4.16)
2:220428095		F>V	A:86	(-1.67, 2.25, 4.60)
2:220428086		T>A	A:89	(1.58, 11.62, 10.14)

2LVC.A | OBSL1.

2LVC.A | OBSL1

General Structure Information

Variant Set Distributions

Mapped Variants

[+] ExAC Missense Variants