Assessment of Structural Intolerance and Durability
General Structure Information 1bhg GUSB human beta-glucuronidase at 2.6 a resolution 2.53Å AUTH S.JAIN,W.B.DRENDEL,Z.W.CHEN,F.S.MATHEWS,W.S.SLY,J.H.GRUBBTITL STRUCTURE OF HUMAN BETA-GLUCURONIDASE REVEALS CANDIDATETITL 2 LYSOSOMAL TARGETING AND ACTIVE-SITE MOTIFS.REF NAT.STRUCT.BIOL. V. 3 375 1996REFN ISSN 1072-8368PMID 8599764DOI 10.1038/NSB0496-375 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z10 CYP2A6 crystal structure of human microsomal p450 2a6 with coumarin bound 1.9Å AUTH J.K.YANO,M.H.HSU,K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURES OF HUMAN MICROSOMAL CYTOCHROME P450 2A6 COMPLEXEDTITL 2 WITH COUMARIN AND METHOXSALENREF NAT.STRUCT.MOL.BIOL. V. 12 822 2005REFN ISSN 1545-9993PMID 16086027DOI 10.1038/NSMB971 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1egd ACADM structure of t255e, e376g mutant of human medium chain acyl- coa dehydrogenase 2.4Å AUTH H.J.LEE,M.WANG,R.PASCHKE,A.NANDY,S.GHISLA,J.J.KIMTITL CRYSTAL STRUCTURES OF THE WILD TYPE AND THETITL 2 GLU376GLY/THR255GLU MUTANT OF HUMAN MEDIUM-CHAINTITL 3 ACYL-COA DEHYDROGENASE: INFLUENCE OF THE LOCATIONTITL 4 OF THE CATALYTIC BASE ON SUBSTRATE SPECIFICITY.REF BIOCHEMISTRY V. 35 12412 1996REFN ISSN […]
General Structure Information 1q68 LCK solution structure of t-cell surface glycoprotein cd4 and proto-oncogene tyrosine-protein kinase lck fragments -1.0Å AUTH P.W.KIM,Z.Y.SUN,S.C.BLACKLOW,G.WAGNER,M.J.ECKTITL A ZINC CLASP STRUCTURE TETHERS LCK TO T CELLTITL 2 CORECEPTORS CD4 AND CD8.REF SCIENCE V. 301 1725 2003REFN ISSN 0036-8075PMID 14500983DOI 10.1126/SCIENCE.1085643 Variant Set Distributions Mapped Variants
General Structure Information 1kf9 GHR phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor 2.6Å AUTH C.A.SCHIFFER,M.ULTSCH,S.WALSH,W.SOMERS,A.M.DE VOS,AUTH 2 A.A.KOSSIAKOFFTITL STRUCTURE OF A PHAGE DISPLAY DERIVED VARIANT OFTITL 2 HUMAN GROWTH HORMONE COMPLEXED TO TWO COPIES OFTITL 3 THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR: EVIDENCETITL […]
General Structure Information 2y5b UBB structure of usp21 in complex with linear diubiquitin-aldehyde 2.7Å AUTH Y.YE,M.AKUTSU,F.REYES-TURCU,R.I.ENCHEV,K.D.WILKINSON,AUTH 2 D.KOMANDERTITL POLYUBIQUITIN BINDING AND CROSS-REACTIVITY IN THE USPTITL 2 DOMAIN DEUBIQUITINASE USP21.REF EMBO REP. V. 12 350 2011REFN ISSN 1469-221XPMID 21399617DOI 10.1038/EMBOR.2011.17 Variant Set Distributions Mapped Variants
General Structure Information 2fj9 DBI high resolution crystal structure of the unliganded human acbp 1.6Å AUTH J.P.TASKINEN,D.M.VAN AALTEN,J.KNUDSEN,R.K.WIERENGATITL HIGH RESOLUTION CRYSTAL STRUCTURES OF UNLIGANDED ANDTITL 2 LIGANDED HUMAN LIVER ACBP REVEAL A NEW MODE OF BINDING FORTITL 3 THE ACYL-COA LIGAND.REF PROTEINS V. 66 229 2006REFN ISSN 0887-3585PMID 17044054DOI 10.1002/PROT.21124 Variant Set Distributions Mapped Variants
General Structure Information 1trn PRSS1 crystal structure of human trypsin 1: unexpected phosphorylation of tyrosine 151 2.2Å AUTH C.GABORIAUD,L.SERRE,O.GUY-CROTTE,E.FOREST,AUTH 2 J.C.FONTECILLA-CAMPSTITL CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTEDTITL 2 PHOSPHORYLATION OF TYR151.REF J.MOL.BIOL. V. 259 995 1996REFN ISSN 0022-2836PMID 8683601DOI 10.1006/JMBI.1996.0376 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3pry HSP90AB1 crystal structure of the middle domain of human hsp90-beta refined at 2.3 a resolution 2.28Å AUTH A.CHAIKUAD,E.PILKA,T.D.SHARPE,C.D.O.COOPER,C.PHILLIPS,AUTH 2 G.BERRIDGE,V.AYINAMPUDI,O.FEDOROV,T.KEATES,AUTH 3 C.THANGARATNARAJAH,T.ZIMMERMANN,M.VOLLMAR,W.W.YUE,K.H.CHE,AUTH 4 T.KROJER,J.R.C.MUNIZ,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 5 J.WEIGELT,A.EDWARDS,A.BULLOCK,AUTH 6 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETATITL 2 REFINED AT 2.3 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 1qki G6PD x-ray structure of human glucose 6-phosphate dehydrogenase (variant canton r459l) complexed with structural nadp+ 3.0Å AUTH S.W.N.AU,S.GOVER,V.M.S.LAM,M.J.ADAMSTITL HUMAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE: THETITL 2 CRYSTAL STRUCTURE REVEALS A STRUCTURAL NADP+TITL 3 MOLECULE AND PROVIDES INSIGHTS INTO ENZYMETITL 4 DEFICIENCYREF STRUCTURE V. 8 293 2000REFN ISSN 0969-2126PMID 10745013DOI 10.1016/S0969-2126(00)00104-0 Variant Set Distributions Ripley’s […]