Assessment of Structural Intolerance and Durability
General Structure Information 1gk4 VIM human vimentin coil 2b fragment (cys2) 2.3Å AUTH S.STRELKOV,H.HERRMANN,N.GEISLER,T.WEDIG,AUTH 2 R.ZIMBELMANN,U.AEBI,P.BURKHARDTITL CONSERVED SEGMENTS 1A AND 2B OF THE INTERMEDIATETITL 2 FILAMENT DIMER: THEIR ATOMIC STRUCTURES AND ROLETITL 3 IN FILAMENT ASSEMBLY.REF EMBO J. V. 21 1255 2002REFN ISSN 0261-4189PMID 11889032DOI 10.1093/EMBOJ/21.6.1255 Variant Set Distributions Mapped Variants
General Structure Information 2aa6 NR3C2 mineralocorticoid receptor s810l mutant with bound progesterone 1.95Å AUTH R.K.BLEDSOE,K.P.MADAUSS,J.A.HOLT,C.J.APOLITO,AUTH 2 M.H.LAMBERT,K.H.PEARCE,T.B.STANLEY,E.L.STEWART,AUTH 3 R.P.TRUMP,T.M.WILLSON,S.P.WILLIAMSTITL A LIGAND-MEDIATED HYDROGEN BOND NETWORK REQUIREDTITL 2 FOR THE ACTIVATION OF THE MINERALOCORTICOIDTITL 3 RECEPTORREF J.BIOL.CHEM. V. 280 31283 2005REFN ISSN 0021-9258PMID 15967794DOI 10.1074/JBC.M504098200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ova C8G x-ray structure of human complement protein c8gamma y83w mutant 1.5Å AUTH B.CHISWELL,L.L.LOVELACE,C.BRANNEN,E.A.ORTLUND,AUTH 2 L.LEBIODA,J.M.SODETZTITL STRUCTURAL FEATURES OF THE LIGAND BINDING SITE ONTITL 2 HUMAN COMPLEMENT PROTEIN C8GAMMA: A MEMBER OF THETITL 3 LIPOCALIN FAMILYREF BIOCHIM.BIOPHYS.ACTA V.1774 637 2007REFN ISSN 0006-3002PMID 17452033DOI 10.1016/J.BBAPAP.2007.03.004 Variant Set Distributions Mapped Variants
General Structure Information 1igr IGF1R type 1 insulin-like growth factor receptor (domains 1-3) 2.6Å AUTH T.P.GARRETT,N.M.MCKERN,M.LOU,M.J.FRENKEL,J.D.BENTLEY,AUTH 2 G.O.LOVRECZ,T.C.ELLEMAN,L.J.COSGROVE,C.W.WARDTITL CRYSTAL STRUCTURE OF THE FIRST THREE DOMAINS OF THE TYPE-1TITL 2 INSULIN-LIKE GROWTH FACTOR RECEPTOR.REF NATURE V. 394 395 1998REFN ISSN 0028-0836PMID 9690478DOI 10.1038/28668 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1kb4 VDR crystal structure of vdr dna-binding domain bound to a canonical direct repeat with three base pair spacer (dr3) response element 2.8Å AUTH P.L.SHAFFER,D.T.GEWIRTHTITL STRUCTURAL BASIS OF VDR-DNA INTERACTIONS ON DIRECTTITL 2 REPEAT RESPONSE ELEMENTS.REF EMBO J. V. 21 2242 2002REFN ISSN 0261-4189PMID 11980721DOI 10.1093/EMBOJ/21.9.2242 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 2rol CD3E structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDINGREF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 1spj KLK1 structure of mature human tissue kallikrein (human kallikrein 1 or klk1) at 1.70 angstrom resolution with vacant active site 1.7Å AUTH G.LAXMIKANTHAN,S.I.BLABER,M.J.BERNETT,I.A.SCARISBRICK,AUTH 2 M.A.JULIANO,M.BLABERTITL 1.70 A X-RAY STRUCTURE OF HUMAN APO KALLIKREIN 1: STRUCTURALTITL 2 CHANGES UPON PEPTIDE INHIBITOR/SUBSTRATE BINDINGREF PROTEINS V. 58 802 2005REFN ISSN 0887-3585PMID 15651049DOI 10.1002/PROT.20368 Variant […]
General Structure Information 1dx5 THBD crystal structure of the thrombin-thrombomodulin complex 2.3Å AUTH P.FUENTES-PRIOR,Y.IWANAGA,R.HUBER,R.PAGILA,G.RUMENNIK,AUTH 2 M.SETO,J.MORSER,D.R.LIGHT,W.BODETITL STRUCTURAL BASIS FOR THE ANTICOAGULANT ACTIVITY OF THETITL 2 THROMBIN-THROMBOMODULIN COMPLEXREF NATURE V. 404 518 2000REFN ISSN 0028-0836PMID 10761923DOI 10.1038/35006683 Variant Set Distributions Mapped Variants
General Structure Information 2hyw ANXA2 human annexin a2 with calcium bound 2.1Å AUTH C.SHAO,F.ZHANG,M.M.KEMP,R.J.LINHARDT,D.M.WAISMAN,AUTH 2 J.F.HEAD,B.A.SEATONTITL CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENTTITL 2 HEPARIN BINDING TO ANNEXIN A2.REF J.BIOL.CHEM. V. 281 31689 2006REFN ISSN 0021-9258PMID 16882661DOI 10.1074/JBC.M604502200 Variant Set Distributions Mapped Variants
General Structure Information 1mmp MMP7 matrilysin complexed with carboxylate inhibitor 2.3Å AUTH M.F.BROWNER,W.W.SMITH,A.L.CASTELHANOTITL MATRILYSIN-INHIBITOR COMPLEXES: COMMON THEMESTITL 2 AMONG METALLOPROTEASES.REF BIOCHEMISTRY V. 34 6602 1995REFN ISSN 0006-2960PMID 7756291DOI 10.1021/BI00020A004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants