Assessment of Structural Intolerance and Durability
General Structure Information 2feb LPA nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a) -1.0Å AUTH S.CHITAYAT,V.KANELIS,M.L.KOSCHINSKY,S.P.SMITHTITL NUCLEAR MAGNETIC RESONANCE (NMR) SOLUTIONTITL 2 STRUCTURE, DYNAMICS, AND BINDING PROPERTIES OF THETITL 3 KRINGLE IV TYPE 8 MODULE OF APOLIPOPROTEIN(A).REF BIOCHEMISTRY V. 46 1732 2007REFN ISSN 0006-2960PMID 17263558DOI 10.1021/BI061814G Variant […]
General Structure Information 4ggf S100A9 crystal structure of mn2+ bound calprotectin 1.6Å AUTH S.M.DAMO,T.E.KEHL-FIE,N.SUGITANI,M.E.HOLT,S.RATHI,AUTH 2 W.J.MURPHY,Y.ZHANG,C.BETZ,L.HENCH,G.FRITZ,E.P.SKAAR,AUTH 3 W.J.CHAZINTITL MOLECULAR BASIS FOR MANGANESE SEQUESTRATION BY CALPROTECTINTITL 2 AND ROLES IN THE INNATE IMMUNE RESPONSE TO INVADINGTITL 3 BACTERIAL PATHOGENS.REF PROC.NATL.ACAD.SCI.USA V. 110 3841 2013REFN ISSN 0027-8424PMID 23431180DOI 10.1073/PNAS.1220341110 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4mqs CHRM2 structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo 3.5Å AUTH A.C.KRUSE,A.M.RING,A.MANGLIK,J.HU,K.HU,K.EITEL,H.HUBNER,AUTH 2 E.PARDON,C.VALANT,P.M.SEXTON,A.CHRISTOPOULOS,C.C.FELDER,AUTH 3 P.GMEINER,J.STEYAERT,W.I.WEIS,K.C.GARCIA,J.WESS,B.K.KOBILKATITL ACTIVATION AND ALLOSTERIC MODULATION OF A MUSCARINICTITL 2 ACETYLCHOLINE RECEPTOR.REF NATURE V. 504 101 2013REFN ISSN 0028-0836PMID 24256733DOI 10.1038/NATURE12735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3lxc GLA interconversion of human lysosomal enzyme specificities 2.35Å AUTH I.B.TOMASIC,M.C.METCALF,A.I.GUCE,N.E.CLARK,S.C.GARMANTITL INTERCONVERSION OF THE SPECIFICITIES OF HUMAN LYSOSOMALTITL 2 ENZYMES ASSOCIATED WITH FABRY AND SCHINDLER DISEASES.REF J.BIOL.CHEM. V. 285 21560 2010REFN ISSN 0021-9258PMID 20444686DOI 10.1074/JBC.M110.118588 Variant Set Distributions Mapped Variants
General Structure Information 2edy PTPRF solution structures of the fn3 domain of human receptor- type tyrosine-protein phosphatase f -1.0Å AUTH M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE FREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1hk0 CRYGD human gamma-d crystallin structure at 1.25 a resolution 1.25Å AUTH A.K.BASAK,O.BATEMAN,C.SLINGSBY,A.PANDE,N.ASHERIE,AUTH 2 O.OGUN,G.BENEDEK,J.PANDETITL HIGH-RESOLUTION X-RAY CRYSTAL STRUCTURES OF HUMANTITL 2 GAMMAD CRYSTALLIN (1.25A) AND THE R58H MUTANTTITL 3 (1.15A) ASSOCIATED WITH ACULEIFORM CATARACTREF J.MOL.BIOL. V. 328 1137 2003REFN ISSN 0022-2836PMID 12729747DOI 10.1016/S0022-2836(03)00375-9 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]
General Structure Information 2xsn TH crystal structure of human tyrosine hydroxylase catalytic domain 2.68Å AUTH J.R.C.MUNIZ,C.D.O.COOPER,W.W.YUE,E.KRYSZTOFINSKA,AUTH 2 F.VON DELFT,S.KNAPP,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTICTITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a9j BPGM human bisphosphoglycerate mutase complexed with 3- phosphoglycerate (17 days) 2.0Å AUTH Y.WANG,L.LIU,Z.WEI,Z.CHENG,Y.LIN,W.GONGTITL SEEING THE PROCESS OF HISTIDINE PHOSPHORYLATION INTITL 2 HUMAN BISPHOSPHOGLYCERATE MUTASEREF J.BIOL.CHEM. V. 281 39642 2006REFN ISSN 0021-9258PMID 17052986DOI 10.1074/JBC.M606421200 Variant Set Distributions Mapped Variants
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants