Assessment of Structural Intolerance and Durability
General Structure Information 1fht SNRPA rna-binding domain of the u1a spliceosomal protein u1a117, nmr, 43 structures -1.0Å AUTH J.M.AVIS,F.H.ALLAIN,P.W.HOWE,G.VARANI,K.NAGAI,AUTH 2 D.NEUHAUSTITL SOLUTION STRUCTURE OF THE N-TERMINAL RNP DOMAIN OFTITL 2 U1A PROTEIN: THE ROLE OF C-TERMINAL RESIDUES INTITL 3 STRUCTURE STABILITY AND RNA BINDING.REF J.MOL.BIOL. V. 257 398 1996REFN ISSN 0022-2836PMID 8609632DOI 10.1006/JMBI.1996.0171 Variant Set […]
General Structure Information 2ebl NR2F1 solution structure of the zinc finger, c4-type domain of human coup transcription factor 1 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,S.WATABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER, C4-TYPETITL 2 DOMAIN OF HUMAN COUP TRANSCRIPTION FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bqq PSAP crystal structure of human saposin d (triclinic) 2.0Å AUTH K.POPOVIC,G.G.PRIVETITL STRUCTURES OF THE HUMAN CERAMIDE ACTIVATOR PROTEINTITL 2 SAPOSIN D.REF ACTA CRYSTALLOGR.,SECT.D V. 64 589 2008REFN ISSN 0907-4449PMID 18453694DOI 10.1107/S0907444908003120 Variant Set Distributions Mapped Variants
General Structure Information 3ktv SRP19 crystal structure of the human srp19/s-domain srp rna complex 3.8Å AUTH K.WILD,G.BANGE,G.BOZKURT,B.SEGNITZ,A.HENDRICKS,I.SINNINGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY OF THE HUMAN ANDTITL 2 ARCHAEAL SIGNAL RECOGNITION PARTICLES.REF ACTA CRYSTALLOGR.,SECT.D V. 66 295 2010REFN ISSN 0907-4449PMID 20179341DOI 10.1107/S0907444910000879 Variant Set Distributions Mapped Variants
General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1rrj TOP1 structural mechanisms of camptothecin resistance by mutations in human topoisomerase i 2.3Å AUTH J.E.CHRENCIK,B.L.STAKER,A.B.BURGIN,P.POURQUIER,AUTH 2 Y.POMMIER,L.STEWART,M.R.REDINBOTITL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY HUMANTITL 2 TOPOISOMERASE I MUTATIONSREF J.MOL.BIOL. V. 339 773 2004REFN ISSN 0022-2836PMID 15165849DOI 10.1016/J.JMB.2004.03.077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k87 EPRS crystal structure of human prolyl-trna synthetase (substrate bound form) 2.3Å AUTH J.SON,E.H.LEE,M.PARK,J.H.KIM,J.KIM,S.KIM,Y.H.JEON,K.Y.HWANGTITL CONFORMATIONAL CHANGES IN HUMAN PROLYL-TRNA SYNTHETASE UPONTITL 2 BINDING OF THE SUBSTRATES PROLINE AND ATP AND THE INHIBITORTITL 3 HALOFUGINONEREF ACTA CRYSTALLOGR.,SECT.D V. 69 2136 2013REFN ISSN 0907-4449DOI 10.1107/S0907444913020556 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3r01 PIM1 the discovery of novel benzofuran-2-carboxylic acids as potent pim-1 inhibitors 2.6Å AUTH Y.XIANG,B.HIRTH,G.ASMUSSEN,H.P.BIEMANN,K.A.BISHOP,A.GOOD,AUTH 2 M.FITZGERALD,T.GLADYSHEVA,A.JAIN,K.JANCSICS,J.LIU,M.METZ,AUTH 3 A.PAPOULIS,R.SKERLJ,J.D.STEPP,R.R.WEITITL THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS ASTITL 2 POTENT PIM-1 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 21 3050 2011REFN ISSN 0960-894XPMID 21507633DOI 10.1016/J.BMCL.2011.03.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2aze RB1 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer 2.55Å AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 Variant Set Distributions Mapped Variants
General Structure Information 3tf2 EIF4E crystal structure of the cap free human translation initiation factor eif4e 2.1Å AUTH N.SIDDIQUI,W.TEMPEL,L.NEDYALKOVA,L.VOLPON,A.K.WERNIMONT,AUTH 2 M.J.OSBORNE,H.W.PARK,K.L.BORDENTITL STRUCTURAL INSIGHTS INTO THE ALLOSTERIC EFFECTS OF 4EBP1 ONTITL 2 THE EUKARYOTIC TRANSLATION INITIATION FACTOR EIF4E.REF J.MOL.BIOL. V. 415 781 2012REFN ISSN 0022-2836PMID 22178476DOI 10.1016/J.JMB.2011.12.002 Variant Set Distributions Mapped Variants