Assessment of Structural Intolerance and Durability
General Structure Information 2ci9 NCK1 nck1 sh2-domain in complex with a dodecaphosphopeptide from epec protein tir 1.5Å AUTH S.FRESE,W.-D.SCHUBERT,A.C.FINDEIS,T.MARQUARDT,Y.S.ROSKE,AUTH 2 T.E.B.STRADAL,D.W.HEINZTITL THE PHOSPHOTYROSINE PEPTIDE BINDING SPECIFICITY OF NCK1 ANDTITL 2 NCK2 SRC HOMOLOGY 2 DOMAINS.REF J.BIOL.CHEM. V. 281 18236 2006REFN ISSN 0021-9258PMID 16636066DOI 10.1074/JBC.M512917200 Variant Set Distributions Mapped Variants
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2h7t IGFBP2 solution structure of the c-terminal domain of insulin-like growth factor binding protein 2 (igfbp-2) -1.0Å AUTH Z.KUANG,S.YAO,D.W.KEIZER,C.C.WANG,L.A.BACH,AUTH 2 B.E.FORBES,J.C.WALLACE,R.S.NORTONTITL STRUCTURE, DYNAMICS AND HEPARIN BINDING OF THETITL 2 C-TERMINAL DOMAIN OF INSULIN-LIKE GROWTHTITL 3 FACTOR-BINDING PROTEIN-2 (IGFBP-2)REF J.MOL.BIOL. V. 364 690 2006REFN ISSN 0022-2836PMID 17020769DOI 10.1016/J.JMB.2006.09.006 Variant Set Distributions Mapped Variants
General Structure Information 2knt COL6A3 the 1.2 angstrom structure of kunitz type domain c5 1.2Å AUTH K.MERIGEAU,B.ARNOUX,D.PERAHIA,K.NORRIS,F.NORRIS,AUTH 2 A.DUCRUIXTITL 1.2 A REFINEMENT OF THE KUNITZ-TYPE DOMAIN FROMTITL 2 THE ALPHA3 CHAIN OF HUMAN TYPE VI COLLAGEN.REF ACTA CRYSTALLOGR.,SECT.D V. 54 306 1998REFN ISSN 0907-4449PMID 9761897DOI 10.1107/S0907444997010846 Variant Set Distributions Mapped Variants
General Structure Information 4g84 HARS crystal structure of human hisrs 2.4Å AUTH Z.XU,Z.WEI,J.J.ZHOU,F.YE,W.S.LO,F.WANG,C.F.LAU,J.WU,AUTH 2 L.A.NANGLE,K.P.CHIANG,X.L.YANG,M.ZHANG,P.SCHIMMELTITL INTERNALLY DELETED HUMAN TRNA SYNTHETASE SUGGESTSTITL 2 EVOLUTIONARY PRESSURE FOR REPURPOSING.REF STRUCTURE V. 20 1470 2012REFN ISSN 0969-2126PMID 22958643DOI 10.1016/J.STR.2012.08.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2he3 GPX2 crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (gpx2) 2.1Å AUTH K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO CYSTEINE MUTANTTITL 2 OF HUMAN GLUTATHIONINE PEROXIDASE 2 (GPX2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4eeg B4GALT1 crystal structure of human m340h-beta-1,4-galactosyltransferase-1 (m340h-b4gal-t1) in complex with glcnac-beta1,6-gal-beta 2.2Å AUTH B.RAMAKRISHNAN,E.BOEGGEMAN,P.K.QASBATITL BINDING OF N-ACETYLGLUCOSAMINE (GLCNAC) BETA 1-6-BRANCHEDTITL 2 OLIGOSACCHARIDE ACCEPTORS TO BETA 4-GALACTOSYLTRANSFERASE ITITL 3 REVEALS A NEW LIGAND BINDING MODE.REF J.BIOL.CHEM. V. 287 28666 2012REFN ISSN 0021-9258PMID 22740701DOI 10.1074/JBC.M112.373514 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2o6l UGT2B7 crystal structure of the udp-glucuronic acid binding domain of the human drug metabolizing udp-glucuronosyltransferase 2b7 1.8Å AUTH M.J.MILEY,A.K.ZIELINSKA,J.E.KEENAN,S.M.BRATTON,AUTH 2 A.RADOMINSKA-PANDYA,M.R.REDINBOTITL CRYSTAL STRUCTURE OF THE COFACTOR-BINDING DOMAINTITL 2 OF THE HUMAN PHASE II DRUG-METABOLISM ENZYMETITL 3 UDP-GLUCURONOSYLTRANSFERASE 2B7.REF J.MOL.BIOL. V. 369 498 2007REFN ISSN 0022-2836PMID 17442341DOI 10.1016/J.JMB.2007.03.066 Variant Set Distributions Mapped […]
General Structure Information 2gk2 CEACAM1 crystal structure of the n terminal domain of human ceacam1 2.2Å AUTH A.FEDAROVICH,J.TOMBERG,R.A.NICHOLAS,C.DAVIESTITL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN CEACAM1: BINDINGTITL 2 TARGET OF THE OPACITY PROTEINS DURING INVASION OF NEISSERIATITL 3 MENINGITIDIS AND N. GONORRHOEAE.REF ACTA CRYSTALLOGR.,SECT.D V. 62 971 2006REFN ISSN 0907-4449PMID 16929097DOI 10.1107/S0907444906020737 Variant Set Distributions […]