Assessment of Structural Intolerance and Durability
General Structure Information 1bhi ATF2 structure of transactivation domain of cre-bp1/atf-2, nmr, 20 structures -1.0Å AUTH A.NAGADOI,K.NAKAZAWA,H.UDA,K.OKUNO,T.MAEKAWA,AUTH 2 S.ISHII,Y.NISHIMURATITL SOLUTION STRUCTURE OF THE TRANSACTIVATION DOMAINTITL 2 OF ATF-2 COMPRISING A ZINC FINGER-LIKE SUBDOMAINTITL 3 AND A FLEXIBLE SUBDOMAIN.REF J.MOL.BIOL. V. 287 593 1999REFN ISSN 0022-2836PMID 10092462DOI 10.1006/JMBI.1999.2620 Variant Set Distributions Mapped Variants
General Structure Information 2d0u IDO1 crystal structure of cyanide bound form of human indoleamine 2,3-dioxygenase 3.4Å AUTH H.SUGIMOTO,S.ODA,T.OTSUKI,T.HINO,T.YOSHIDA,Y.SHIROTITL CRYSTAL STRUCTURE OF HUMAN INDOLEAMINETITL 2 2,3-DIOXYGENASE: CATALYTIC MECHANISM OF O2TITL 3 INCORPORATION BY A HEME-CONTAINING DIOXYGENASE.REF PROC.NATL.ACAD.SCI.USA V. 103 2611 2006REFN ISSN 0027-8424PMID 16477023DOI 10.1073/PNAS.0508996103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2o0l SRM human spermidine synthase 1.99Å AUTH H.WU,J.MIN,Y.IKEGUCHI,H.ZENG,A.DONG,P.LOPPNAU,A.E.PEGG,AUTH 2 A.N.PLOTNIKOVTITL STRUCTURE AND MECHANISM OF SPERMIDINE SYNTHASES.REF BIOCHEMISTRY V. 46 8331 2007REFN ISSN 0006-2960PMID 17585781DOI 10.1021/BI602498K Variant Set Distributions Mapped Variants
General Structure Information 2h32 VPREB1 crystal structure of the pre-b cell receptor 2.7Å AUTH A.J.BANKOVICH,S.RAUNSER,Z.S.JUO,T.WALZ,M.M.DAVIS,K.C.GARCIATITL STRUCTURAL INSIGHT INTO PRE-B CELL RECEPTOR FUNCTIONREF SCIENCE V. 316 291 2007REFN ISSN 0036-8075PMID 17431183DOI 10.1126/SCIENCE.1139412 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii0 GOT1 crystal structure of human glutamate oxaloacetate transaminase 1 (got1) 2.05Å AUTH E.UGOCHUKWU,E.PILKA,C.COOPER,J.E.BRAY,W.W.YUE,J.MUNIZ,AUTH 2 A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTAMATE OXALOACETATETITL 2 TRANSAMINASE 1 (GOT1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fbn PLCG1 insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains 2.4Å AUTH T.D.BUNNEY,D.ESPOSITO,C.MAS-DROUX,E.LAMBER,R.W.BAXENDALE,AUTH 2 M.MARTINS,A.COLE,D.SVERGUN,P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND FUNCTIONAL INTEGRATION OF THE PLCGAMMATITL 2 INTERACTION DOMAINS CRITICAL FOR REGULATORY MECHANISMS ANDTITL 3 SIGNALING DEREGULATION.REF STRUCTURE V. 20 2062 2012REFN […]
General Structure Information 3lhr ZNF24 crystal structure of the scan domain from human znf24 1.9Å AUTH B.F.VOLKMAN,F.C.PETERSON,C.A.BINGMAN,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE SCAN DOMAIN FROM HUMAN ZNF24REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4j15 DARS crystal structure of human cytosolic aspartyl-trna synthetase, a component of multi-trna synthetase complex 2.24Å AUTH K.R.KIM,S.H.PARK,H.S.KIM,K.H.RHEE,B.-G.KIM,D.G.KIM,M.S.PARK,AUTH 2 H.-J.KIM,S.KIM,B.W.HANTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ASPARTYL-TRNATITL 2 SYNTHETASE, A COMPONENT OF MULTI-TRNA SYNTHETASE COMPLEXREF PROTEINS V. 81 1840 2013REFN ISSN 0887-3585PMID 23609930DOI 10.1002/PROT.24306 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1g9l PABPC1 solution structure of the pabc domain of human poly(a) binding protein -1.0Å AUTH G.KOZLOV,J.F.TREMPE,K.KHALEGHPOUR,A.KAHVEJIAN,AUTH 2 I.EKIEL,K.GEHRINGTITL STRUCTURE AND FUNCTION OF THE C-TERMINAL PABCTITL 2 DOMAIN OF HUMAN POLY(A)-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 98 4409 2001REFN ISSN 0027-8424PMID 11287632DOI 10.1073/PNAS.071024998 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2dbf NFKB1 solution structure of the death domain in human nuclear factor nf-kappa-b p105 subunit -1.0Å AUTH K.SAITO,M.INOUE,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEATH DOMAIN IN HUMANTITL 2 NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants