Assessment of Structural Intolerance and Durability
General Structure Information 1ga5 NR1D1 crystal structure of the orphan nuclear receptor rev- erb(alpha) dna-binding domain bound to its cognate response element 2.4Å AUTH M.L.SIERK,Q.ZHAO,F.RASTINEJADTITL DNA DEFORMABILITY AS A RECOGNITION FEATURE IN THETITL 2 REVERB RESPONSE ELEMENTREF BIOCHEMISTRY V. 40 12833 2001REFN ISSN 0006-2960PMID 11669620DOI 10.1021/BI011086R Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1vca VCAM1 crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 angstroms resolution 1.8Å AUTH E.Y.JONES,K.HARLOS,M.J.BOTTOMLEY,R.C.ROBINSON,AUTH 2 P.C.DRISCOLL,R.M.EDWARDS,J.M.CLEMENTS,T.J.DUDGEON,AUTH 3 D.I.STUARTTITL CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENTTITL 2 OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ATITL 3 RESOLUTION.REF NATURE V. 373 539 1995REFN ISSN 0028-0836PMID 7531291DOI 10.1038/373539A0 Variant Set […]
General Structure Information 3cfw SELL l-selectin lectin and egf domains 2.2Å AUTH P.MEHTA,R.P.MCEVERTITL STRUCTURE OF LECTIN AND EGF DOMAINS OF L-SELECTINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k6m PFKFB1 crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2.4Å AUTH Y.H.LEE,Y.LI,K.UYEDA,C.A.HASEMANNTITL TISSUE-SPECIFIC STRUCTURE/FUNCTION DIFFERENTIATION OF THETITL 2 LIVER ISOFORM OFTITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE.REF J.BIOL.CHEM. V. 278 523 2003REFN ISSN 0021-9258PMID 12379646DOI 10.1074/JBC.M209105200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qc8 GLUL crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate 2.6Å AUTH W.W.KRAJEWSKI,R.COLLINS,L.HOLMBERG-SCHIAVONE,T.A.JONES,AUTH 2 T.KARLBERG,S.L.MOWBRAYTITL CRYSTAL STRUCTURES OF MAMMALIAN GLUTAMINE SYNTHETASESTITL 2 ILLUSTRATE SUBSTRATE-INDUCED CONFORMATIONAL CHANGES ANDTITL 3 PROVIDE OPPORTUNITIES FOR DRUG AND HERBICIDE DESIGN.REF J.MOL.BIOL. V. 375 217 2008REFN ISSN 0022-2836PMID 18005987DOI 10.1016/J.JMB.2007.10.029 Variant Set […]
General Structure Information 2wk3 IDE crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) 2.59Å AUTH Q.GUO,M.MANOLOPOULOU,Y.BIAN,A.B.SCHILLING,W.J.TANGTITL MOLECULAR BASIS FOR THE RECOGNITION AND CLEAVAGESTITL 2 OF IGF-II, TGF-ALPHA, AND AMYLIN BY HUMAN INSULINTITL 3 DEGRADING ENZYME.REF J.MOL.BIOL. V. 395 430 2010REFN ISSN 0022-2836PMID 19896952DOI 10.1016/J.JMB.2009.10.072 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4h27 SDS modulating the function of human serine racemase and human serine dehydratase by protein engineering 1.3Å AUTH C.Y.WANG,S.C.KU,C.C.LEE,A.H.WANGTITL MODULATING THE FUNCTION OF HUMAN SERINE RACEMASE AND HUMANTITL 2 SERINE DEHYDRATASE BY PROTEIN ENGINEERING.REF PROTEIN ENG.DES.SEL. V. 25 741 2012REFN ISSN 1741-0126PMID 23112234DOI 10.1093/PROTEIN/GZS078 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2oyt UNG crystal structure of ung2/dna(tm) 2.0Å AUTH J.B.PARKER,M.A.BIANCHET,D.J.KROSKY,J.I.FRIEDMAN,L.M.AMZEL,AUTH 2 J.T.STIVERSTITL ENZYMATIC CAPTURE OF AN EXTRAHELICAL THYMINE IN THE SEARCHTITL 2 FOR URACIL IN DNA.REF NATURE V. 449 433 2007REFN ISSN 0028-0836PMID 17704764DOI 10.1038/NATURE06131 Variant Set Distributions Mapped Variants
General Structure Information 1cqt POU2F1 crystal structure of a ternary complex containing an oca-b peptide, the oct-1 pou domain, and an octamer element 3.2Å AUTH D.CHASMAN,K.CEPEK,P.A.SHARP,C.O.PABOTITL CRYSTAL STRUCTURE OF AN OCA-B PEPTIDE BOUND TO ANTITL 2 OCT-1 POU DOMAIN/OCTAMER DNA COMPLEX: SPECIFICTITL 3 RECOGNITION OF A PROTEIN-DNA INTERFACE.REF GENES DEV. V. 13 2650 1999REFN ISSN […]
General Structure Information 1avf PGC activation intermediate 2 of human gastricsin from human stomach 2.36Å AUTH A.R.KHAN,M.M.CHERNEY,N.I.TARASOVA,M.N.JAMESTITL STRUCTURAL CHARACTERIZATION OF ACTIVATIONTITL 2 INTERMEDIATE 2 ON THE PATHWAY TO HUMANTITL 3 GASTRICSIN.REF NAT.STRUCT.BIOL. V. 4 1010 1997REFN ISSN 1072-8368PMID 9406551DOI 10.1038/NSB1297-1010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants