Assessment of Structural Intolerance and Durability
General Structure Information 4k2p TIAM1 the structure of a quintuple mutant of the tiam1 ph-cc-ex domain 1.98Å AUTH M.JOSHI,L.GAKHAR,E.J.FUENTESTITL HIGH-RESOLUTION STRUCTURE OF THE TIAM1 PHN-CC-EX DOMAIN.REF ACTA CRYSTALLOGR.,SECT.F V. 69 744 2013REFN ESSN 1744-3091PMID 23832200DOI 10.1107/S1744309113014206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hk0 GRB10 crystal structure of the ra and ph domains of grb10 2.6Å AUTH R.S.DEPETRIS,J.WU,S.R.HUBBARDTITL STRUCTURAL AND FUNCTIONAL STUDIES OF THE RAS-ASSOCIATING ANDTITL 2 PLECKSTRIN-HOMOLOGY DOMAINS OF GRB10 AND GRB14.REF NAT.STRUCT.MOL.BIOL. V. 16 833 2009REFN ISSN 1545-9993PMID 19648926DOI 10.1038/NSMB.1642 Variant Set Distributions Mapped Variants
General Structure Information 2l33 ILF3 solution nmr structure of drbm 2 domain of interleukin enhancer- binding factor 3 from homo sapiens, northeast structural genomics consortium target hr4527e -1.0Å AUTH G.LIU,H.JANJUA,R.XIAO,T.B.ACTON,J.EVERETT,G.T.MONTELIONETITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4527EREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z68 FAP crystal structure of human fibroblast activation protein alpha 2.6Å AUTH K.AERTGEERTS,I.LEVIN,L.SHI,G.P.SNELL,A.JENNINGS,G.S.PRASAD,AUTH 2 Y.ZHANG,M.L.KRAUS,S.SALAKIAN,V.SRIDHAR,R.WIJNANDS,AUTH 3 M.G.TENNANTTITL STRUCTURAL AND KINETIC ANALYSIS OF THE SUBSTRATE SPECIFICITYTITL 2 OF HUMAN FIBROBLAST ACTIVATION PROTEIN ALPHA.REF J.BIOL.CHEM. V. 280 19441 2005REFN ISSN 0021-9258PMID 15809306DOI 10.1074/JBC.C500092200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zmq DEFA6 crystal structure of human alpha-defensin-6 2.1Å AUTH A.SZYK,Z.WU,K.TUCKER,D.YANG,W.LU,J.LUBKOWSKITITL CRYSTAL STRUCTURES OF HUMAN {ALPHA}-DEFENSINS HNP4, HD5, ANDTITL 2 HD6.REF PROTEIN SCI. V. 15 2749 2006REFN ISSN 0961-8368PMID 17088326DOI 10.1110/PS.062336606 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3vhx KIF23 the crystal structure of arf6-mklp1 (mitotic kinesin-like protein 1) complex 2.81Å AUTH H.MAKYIO,M.OHGI,T.TAKEI,S.TAKAHASHI,H.TAKATSU,Y.KATOH,AUTH 2 A.HANAI,T.UEDA,Y.KANAHO,Y.XIE,H.W.SHIN,H.KAMIKUBO,M.KATAOKA,AUTH 3 M.KAWASAKI,R.KATO,S.WAKATSUKI,K.NAKAYAMATITL STRUCTURAL BASIS FOR ARF6-MKLP1 COMPLEX FORMATION ON THETITL 2 FLEMMING BODY RESPONSIBLE FOR CYTOKINESISREF EMBO J. V. 31 2590 2012REFN ISSN 0261-4189PMID 22522702DOI 10.1038/EMBOJ.2012.89 Variant Set Distributions Mapped Variants
General Structure Information 4egx KIF1A crystal structure of kif1a cc1-fha tandem 2.51Å AUTH L.HUO,Y.YUE,J.REN,J.YU,J.LIU,Y.YU,F.YE,T.XU,M.ZHANG,W.FENGTITL THE CC1-FHA TANDEM AS A CENTRAL HUB FOR CONTROLLING THETITL 2 DIMERIZATION AND ACTIVATION OF KINESIN-3 KIF1AREF STRUCTURE V. 20 1550 2012REFN ISSN 0969-2126PMID 22863567DOI 10.1016/J.STR.2012.07.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yuq ITK solution structure of the sh3 domain of human tyrosine- protein kinase itk/tsk -1.0Å AUTH H.ABE,K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,AUTH 2 T.HARADA,S.WATANABE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE ITK/TSKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t5c CENPE crystal structure of the motor domain of human kinetochore protein cenp-e 2.5Å AUTH I.GARCIA-SAEZ,T.YEN,R.H.WADE,F.KOZIELSKITITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF THE HUMANTITL 2 KINETOCHORE PROTEIN CENP-E.REF J.MOL.BIOL. V. 340 1107 2004REFN ISSN 0022-2836PMID 15236970DOI 10.1016/J.JMB.2004.05.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]