Assessment of Structural Intolerance and Durability
General Structure Information 2j3s FLNA crystal structure of the human filamin a ig domains 19 to 21 2.5Å AUTH Y.LAD,T.-R.KIEMA,P.JIANG,O.T.PENTIKANEN,C.H.COLES,AUTH 2 I.D.CAMPBELL,D.A.CALDERWOOD,J.YLANNETITL STRUCTURE OF THREE TANDEM FILAMIN DOMAINS REVEALSTITL 2 AUTO-INHIBITION OF LIGAND-BINDING.REF EMBO J. V. 26 3993 2007REFN ISSN 0261-4189PMID 17690686DOI 10.1038/SJ.EMBOJ.7601827 Variant Set Distributions Mapped Variants
General Structure Information 3qk3 CRYBB3 crystal structure of human beta-crystallin b3 1.95Å Variant Set Distributions Mapped Variants
General Structure Information 2c0y CTSS the crystal structure of a cys25ala mutant of human procathepsin s 2.1Å AUTH G.KAULMANN,G.J.PALM,K.SCHILLING,R.HILGENFELD,AUTH 2 B.WIEDERANDERSTITL THE CRYSTAL STRUCTURE OF A CYS25 -> ALA MUTANT OFTITL 2 HUMAN PROCATHEPSIN S ELUCIDATES ENZYME-PROSEQUENCETITL 3 INTERACTIONS.REF PROTEIN SCI. V. 15 2619 2006REFN ISSN 0961-8368PMID 17075137DOI 10.1110/PS.062401806 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3sn5 CYP7A1 crystal structure of human cyp7a1 in complex with cholest-4-en-3-one 2.75Å AUTH N.STRUSHKEVICH,W.TEMPEL,F.MACKENZIE,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CYP7A1 IN COMPLEX WITHTITL 2 CHOLEST-4-EN-3-ONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zw3 GJB2 structure of the connexin-26 gap junction channel at 3.5 angstrom resolution 3.5Å AUTH S.MAEDA,S.NAKAGAWA,M.SUGA,E.YAMASHITA,A.OSHIMA,AUTH 2 Y.FUJIYOSHI,T.TSUKIHARATITL STRUCTURE OF THE CONNEXIN 26 GAP JUNCTION CHANNELTITL 2 AT 3.5 A RESOLUTIONREF NATURE V. 458 597 2009REFN ISSN 0028-0836PMID 19340074DOI 10.1038/NATURE07869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2yob AGXT high resolution agxt_m structure 1.9Å AUTH N.MESA-TORRES,I.FABELO-ROSA,D.RIVEROL,C.YUNTA,A.ALBERT,AUTH 2 E.SALIDO,A.L.PEYTITL THE ROLE OF PROTEIN DENATURATION ENERGETICS AND MOLECULARTITL 2 CHAPERONES IN THE AGGREGATION AND MISTARGETING OF MUTANTSTITL 3 CAUSING PRIMARY HYPEROXALURIA TYPE IREF PLOS ONE V. 8 71963 2013REFN ISSN 1932-6203PMID 24205397DOI 10.1371/JOURNAL.PONE.0071963 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ar7 AK4 crystal structure of human adenylate kinase 4, ak4 2.15Å AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,O.FEDOROV,J.WEIGELT,AUTH 2 G.BUNKOCZI,E.UGOCHUKWU,J.DEBRECZENI,F.NIESEN,F.VON DELFT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN ADENYLATE KINASE 4, AK4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2x8b ACHE crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-ii 2.95Å AUTH E.CARLETTI,J.P.COLLETIER,F.DUPEUX,M.TROVASLET,AUTH 2 P.MASSON,F.NACHONTITL STRUCTURAL EVIDENCE THAT HUMANTITL 2 ACETYLCHOLINESTERASE INHIBITED BY TABUN AGESTITL 3 THROUGH O-DEALKYLATIONREF J.MED.CHEM. V. 53 4002 2010REFN ISSN 0022-2623PMID 20408548DOI 10.1021/JM901853B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4ivc JAK1 jak1 kinase (jh1 domain) in complex with the inhibitor (trans-4-{2- [(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)- yl}cyclohexyl)acetonitrile 2.35Å AUTH M.ZAK,C.A.HURLEY,S.I.WARD,P.BERGERON,K.BARRETT,M.BALAZS,AUTH 2 W.S.BLAIR,R.BULL,P.CHAKRAVARTY,C.CHANG,P.CRACKETT,AUTH 3 G.DESHMUKH,J.DEVOSS,P.S.DRAGOVICH,C.EIGENBROT,C.ELLWOOD,AUTH 4 S.GAINES,N.GHILARDI,P.GIBBONS,S.GRADL,P.GRIBLING,C.HAMMAN,AUTH 5 E.HARSTAD,P.HEWITT,A.JOHNSON,T.JOHNSON,J.R.KENNY,AUTH 6 M.F.KOEHLER,P.BIR KOHLI,S.LABADIE,W.P.LEE,J.LIAO,M.LIIMATTA,AUTH 7 R.MENDONCA,R.NARUKULLA,R.PULK,A.REEVE,S.SAVAGE,S.SHIA,AUTH 8 M.STEFFEK,S.UBHAYAKAR,A.VAN ABBEMA,I.ALIAGAS,AUTH 9 B.AVITABILE-WOO,Y.XIAO,J.YANG,J.J.KULAGOWSKITITL IDENTIFICATION OF C-2 HYDROXYETHYL IMIDAZOPYRROLOPYRIDINESTITL 2 AS POTENT JAK1 INHIBITORS WITH FAVORABLE PHYSICOCHEMICALTITL 3 PROPERTIES AND HIGH […]
General Structure Information 2dlh PTPRD solution structure of the second fn3 domain of human receptor-type tyrosine-protein phosphatase delta -1.0Å AUTH K.SEIMIYA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASETITL 3 DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants