Assessment of Structural Intolerance and Durability
General Structure Information 2v7c NR1D2 crystal structure of rev-erb beta 2.4Å AUTH E.-J.WOO,D.G.JEONG,M.-Y.LIM,S.J.KIM,K.-J.KIM,AUTH 2 S.-M.YOON,B.-C.PARK,S.E.RYUTITL STRUCTURAL INSIGHT INTO THE CONSTITUTIVETITL 2 REPRESSION FUNCTION OF THE NUCLEAR RECEPTORTITL 3 REV-ERBBETAREF J.MOL.BIOL. V. 373 735 2007REFN ISSN 0022-2836PMID 17870090DOI 10.1016/J.JMB.2007.08.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ldj CUL1 structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex 3.0Å AUTH N.ZHENG,B.A.SCHULMAN,L.SONG,J.J.MILLER,P.D.JEFFREY,AUTH 2 P.WANG,C.CHU,D.M.KOEPP,S.J.ELLEDGE,M.PAGANO,AUTH 3 R.C.CONAWAY,J.W.CONAWAY,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCFTITL 2 UBIQUITIN LIGASE COMPLEX.REF NATURE V. 416 703 2002REFN ISSN 0028-0836PMID 11961546DOI 10.1038/416703A Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3g4h RGN crystal structure of human senescence marker protein-30 (zinc bound) 1.92Å AUTH S.CHAKRABORTI,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN SENESCENCE MARKER PROTEIN 30:TITL 2 INSIGHTS LINKING STRUCTURAL, ENZYMATIC, AND PHYSIOLOGICALTITL 3 FUNCTIONS .REF BIOCHEMISTRY V. 49 3436 2010REFN ISSN 0006-2960PMID 20329768DOI 10.1021/BI9022297 Variant Set Distributions Mapped Variants
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kkt ATXN7L3 solution structure of the sca7 domain of human ataxin-7-l3 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1y7q ZNF174 mammalian scan domain dimer is a domain-swapped homologue of the hiv capsid c-terminal domain -1.0Å AUTH D.IVANOV,J.R.STONE,J.L.MAKI,T.COLLINS,G.WAGNERTITL MAMMALIAN SCAN DOMAIN DIMER IS A DOMAIN-SWAPPEDTITL 2 HOMOLOG OF THE HIV CAPSID C-TERMINAL DOMAINREF MOL.CELL V. 17 137 2005REFN ISSN 1097-2765PMID 15629724DOI 10.1016/J.MOLCEL.2004.12.015 Variant Set Distributions Mapped Variants
General Structure Information 2epw ZNF268 solution structure of the 24th c2h2 type zinc finger domain of zinc finger protein 268 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 24TH C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 268REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uvl BIRC3 human bir3 domain of baculoviral inhibitor of apoptosis repeat-containing 3 (birc3) 1.91Å AUTH M.D.HERMAN,M.MOCHE,S.FLODIN,M.WELIN,L.TRESAUGUES,AUTH 2 I.JOHANSSON,M.NILSSON,P.NORDLUND,T.NYMANTITL STRUCTURES OF BIR DOMAINS FROM HUMAN NAIP AND CIAP2.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1091 2009REFN ISSN 1744-3091PMID 19923725DOI 10.1107/S1744309109038597 Variant Set Distributions Mapped Variants
General Structure Information 2hye CUL4A crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3.1Å AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175 Variant Set Distributions Mapped Variants
General Structure Information 2hye CUL4A crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3.1Å AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175 Variant Set Distributions Mapped Variants