Assessment of Structural Intolerance and Durability
General Structure Information 2hye CUL4A crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3.1Å AUTH S.ANGERS,T.LI,X.YI,M.J.MACCOSS,R.T.MOON,N.ZHENGTITL MOLECULAR ARCHITECTURE AND ASSEMBLY OF THETITL 2 DDB1-CUL4A UBIQUITIN LIGASE MACHINERY.REF NATURE V. 443 590 2006REFN ISSN 0028-0836PMID 16964240DOI 10.1038/NATURE05175 Variant Set Distributions Mapped Variants
General Structure Information 1bwn BTK ph domain and btk motif from brutons tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4 2.1Å AUTH E.BARALDI,K.D.CARUGO,M.HYVONEN,P.L.SURDO,A.M.RILEY,AUTH 2 B.V.POTTER,R.OBRIEN,J.E.LADBURY,M.SARASTETITL STRUCTURE OF THE PH DOMAIN FROM BRUTONS TYROSINE KINASE INTITL 2 COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE.REF STRUCTURE FOLD.DES. V. 7 449 1999REFN ISSN 0969-2126PMID 10196129DOI 10.1016/S0969-2126(99)80057-4 Variant Set Distributions Ripley’s K […]
General Structure Information 1bwn BTK ph domain and btk motif from brutons tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4 2.1Å AUTH E.BARALDI,K.D.CARUGO,M.HYVONEN,P.L.SURDO,A.M.RILEY,AUTH 2 B.V.POTTER,R.OBRIEN,J.E.LADBURY,M.SARASTETITL STRUCTURE OF THE PH DOMAIN FROM BRUTONS TYROSINE KINASE INTITL 2 COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE.REF STRUCTURE FOLD.DES. V. 7 449 1999REFN ISSN 0969-2126PMID 10196129DOI 10.1016/S0969-2126(99)80057-4 Variant Set Distributions Ripley’s K […]
General Structure Information 1bwn BTK ph domain and btk motif from brutons tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4 2.1Å AUTH E.BARALDI,K.D.CARUGO,M.HYVONEN,P.L.SURDO,A.M.RILEY,AUTH 2 B.V.POTTER,R.OBRIEN,J.E.LADBURY,M.SARASTETITL STRUCTURE OF THE PH DOMAIN FROM BRUTONS TYROSINE KINASE INTITL 2 COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE.REF STRUCTURE FOLD.DES. V. 7 449 1999REFN ISSN 0969-2126PMID 10196129DOI 10.1016/S0969-2126(99)80057-4 Variant Set Distributions Ripley’s K […]
General Structure Information 2enn PRKCQ solution structure of the first c1 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C1 DOMAIN FROMTITL 2 HUMAN PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ro1 TRIM28 nmr solution structures of human kap1 phd finger-bromodomain -1.0Å AUTH L.ZENG,K.L.YAP,A.V.IVANOV,X.WANG,S.MUJTABA,AUTH 2 O.PLOTNIKOVA,F.J.RAUSCHER,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO HUMAN KAP1 PHDTITL 2 FINGER-BROMODOMAIN AND ITS ROLE IN GENE SILENCINGREF NAT.STRUCT.MOL.BIOL. V. 15 626 2008REFN ISSN 1545-9993PMID 18488044DOI 10.1038/NSMB.1416 Variant Set Distributions Mapped Variants
General Structure Information 1q7l ACY1 zn-binding domain of the t347g mutant of human aminoacylase- i 1.4Å AUTH H.A.LINDNER,V.V.LUNIN,A.ALARY,R.HECKER,M.CYGLER,AUTH 2 R.MENARDTITL ESSENTIAL ROLES OF ZINC LIGATION AND ENZYMETITL 2 DIMERIZATION FOR CATALYSIS IN THETITL 3 AMINOACYLASE-1/M20 FAMILY.REF J.BIOL.CHEM. V. 278 44496 2003REFN ISSN 0021-9258PMID 12933810DOI 10.1074/JBC.M304233200 Variant Set Distributions Mapped Variants
General Structure Information 1q7l ACY1 zn-binding domain of the t347g mutant of human aminoacylase- i 1.4Å AUTH H.A.LINDNER,V.V.LUNIN,A.ALARY,R.HECKER,M.CYGLER,AUTH 2 R.MENARDTITL ESSENTIAL ROLES OF ZINC LIGATION AND ENZYMETITL 2 DIMERIZATION FOR CATALYSIS IN THETITL 3 AMINOACYLASE-1/M20 FAMILY.REF J.BIOL.CHEM. V. 278 44496 2003REFN ISSN 0021-9258PMID 12933810DOI 10.1074/JBC.M304233200 Variant Set Distributions Mapped Variants
General Structure Information 1q7l ACY1 zn-binding domain of the t347g mutant of human aminoacylase- i 1.4Å AUTH H.A.LINDNER,V.V.LUNIN,A.ALARY,R.HECKER,M.CYGLER,AUTH 2 R.MENARDTITL ESSENTIAL ROLES OF ZINC LIGATION AND ENZYMETITL 2 DIMERIZATION FOR CATALYSIS IN THETITL 3 AMINOACYLASE-1/M20 FAMILY.REF J.BIOL.CHEM. V. 278 44496 2003REFN ISSN 0021-9258PMID 12933810DOI 10.1074/JBC.M304233200 Variant Set Distributions Mapped Variants
General Structure Information 2jed PRKCQ the crystal structure of the kinase domain of the protein kinase c theta in complex with nvp-xaa228 at 2.32a resolution. 2.32Å AUTH W.STARK,F.BITSCH,A.BERNER,F.BUELENS,P.GRAFF,AUTH 2 H.DEPERSIN,G.FENDRICH,M.GEISER,R.KNECHT,J.RAHUEL,AUTH 3 G.RUMMEL,J.M.SCHLAEPPI,R.SCHMITZ,A.STRAUSS,J.WAGNERTITL THE CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF THETITL 2 PROTEIN KINASE C THETA IN COMPLEX WITH NVP-XAA228REF TO BE PUBLISHEDREFN Variant Set […]