Assessment of Structural Intolerance and Durability
General Structure Information 4hc7 GATA3 crystal structure of the full dna binding domain of gata3-complex 2 2.65Å AUTH Y.CHEN,D.L.BATES,R.DEY,P.H.CHEN,A.C.MACHADO,AUTH 2 I.A.LAIRD-OFFRINGA,R.ROHS,L.CHENTITL DNA BINDING BY GATA TRANSCRIPTION FACTOR SUGGESTS MECHANISMSTITL 2 OF DNA LOOPING AND LONG-RANGE GENE REGULATION.REF CELL REP V. 2 1197 2012REFN ESSN 2211-1247PMID 23142663DOI 10.1016/J.CELREP.2012.10.012 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1vd4 GTF2E1 solution structure of the zinc finger domain of tfiie alpha -1.0Å AUTH M.OKUDA,A.TANAKA,Y.ARAI,M.SATOH,H.OKAMURA,AUTH 2 A.NAGADOI,F.HANAOKA,Y.OHKUMA,Y.NISHIMURATITL A NOVEL ZINC FINGER STRUCTURE IN THE LARGE SUBUNITTITL 2 OF HUMAN GENERAL TRANSCRIPTION FACTOR TFIIE.REF J.BIOL.CHEM. V. 279 51395 2004REFN ISSN 0021-9258PMID 15385556DOI 10.1074/JBC.M404722200 Variant Set Distributions Mapped Variants
General Structure Information 2l30 PARP1 human parp-1 zinc finger 1 -1.0Å AUTH S.EUSTERMANN,H.VIDELER,J.YANG,P.T.COLE,D.GRUSZKA,AUTH 2 D.VERPREINTSEV,D.NEUHAUSTITL THE DNA-BINDING DOMAIN OF HUMAN PARP-1 INTERACTS WITH DNATITL 2 SINGLE-STRAND BREAKS AS A MONOMER THROUGH ITS SECOND ZINCTITL 3 FINGER.REF J.MOL.BIOL. 2011REFN ESSN 1089-8638DOI 10.1016/J.JMB.2011.01.034 Variant Set Distributions Mapped Variants
General Structure Information 3cw1 SNRNP70 crystal structure of human spliceosomal u1 snrnp 5.49Å AUTH D.A.POMERANZ KRUMMEL,C.OUBRIDGE,A.K.LEUNG,J.LI,K.NAGAITITL CRYSTAL STRUCTURE OF HUMAN SPLICEOSOMAL U1 SNRNP AT 5.5 ATITL 2 RESOLUTION.REF NATURE V. 458 475 2009REFN ISSN 0028-0836PMID 19325628DOI 10.1038/NATURE07851 Variant Set Distributions Mapped Variants
General Structure Information 2k1p ZRANB2 solution structure of the second zinc finger domain of zranb2/znf265 -1.0Å AUTH F.E.LOUGHLIN,R.E.MANSFIELD,P.M.VAZ,W.LEUNG,AUTH 2 S.SETIYAPUTRA,R.P.GRANT,E.S.CHEN,R.GAMSJAEGER,AUTH 3 J.P.MACKAYTITL THE ZINC FINGERS OF THE SR-PROEIN ZRANB2 RECOGNIZETITL 2 5SPLICE SITE-LIKE SEQUENCES AND CONSTITUTE ATITL 3 DISTINCT CLASS OF RNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1n0z ZRANB2 solution structure of the first zinc-finger domain from znf265 -1.0Å AUTH C.A.PLAMBECK,A.H.Y.KWAN,D.J.ADAMS,B.J.WESTMAN,AUTH 2 L.VAN DER WEYDEN,R.L.MEDCALF,B.J.MORRIS,J.P.MACKAYTITL THE STRUCTURE OF THE ZINC FINGER DOMAIN FROM HUMANTITL 2 SPLICING FACTOR ZNF265 FOLDREF J.BIOL.CHEM. V. 278 22805 2003REFN ISSN 0021-9258PMID 12657633DOI 10.1074/JBC.M301896200 Variant Set Distributions Mapped Variants
General Structure Information 2d9k TRAFD1 solution structure of the zf-traf domain of fln29 gene product -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-TRAF DOMAIN OF FLN29TITL 2 GENE PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a66 NR5A2 human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter 2.2Å AUTH I.H.SOLOMON,J.M.HAGER,R.SAFI,D.P.MCDONNELL,AUTH 2 M.R.REDINBO,E.A.ORTLUNDTITL CRYSTAL STRUCTURE OF THE HUMAN LRH-1 DBD-DNATITL 2 COMPLEX REVEALS FTZ-F1 DOMAIN POSITIONING ISTITL 3 REQUIRED FOR RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 354 1091 2005REFN ISSN 0022-2836PMID 16289203DOI 10.1016/J.JMB.2005.10.009 Variant […]
General Structure Information 2kkr ATXN7 solution structure of sca7 zinc finger domain from human ataxin-7 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants