Assessment of Structural Intolerance and Durability
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants
General Structure Information 2v7c NR1D2 crystal structure of rev-erb beta 2.4Å AUTH E.-J.WOO,D.G.JEONG,M.-Y.LIM,S.J.KIM,K.-J.KIM,AUTH 2 S.-M.YOON,B.-C.PARK,S.E.RYUTITL STRUCTURAL INSIGHT INTO THE CONSTITUTIVETITL 2 REPRESSION FUNCTION OF THE NUCLEAR RECEPTORTITL 3 REV-ERBBETAREF J.MOL.BIOL. V. 373 735 2007REFN ISSN 0022-2836PMID 17870090DOI 10.1016/J.JMB.2007.08.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bkf NBR1 structure of the pb1 domain of nbr1 1.56Å AUTH S.MUELLER,I.KURSULA,P.ZOU,M.WILMANNSTITL CRYSTAL STRUCTURE OF THE PB1 DOMAIN OF NBR1REF FEBS LETT. V. 580 341 2006REFN ISSN 0014-5793PMID 16376336DOI 10.1016/J.FEBSLET.2005.12.021 Variant Set Distributions Mapped Variants
General Structure Information 2ebt KLF5 solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THREE TANDEM REPEATS OFTITL 2 ZF-C2H2 DOMAINS FROM HUMAN KRUPPEL-LIKE FACTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jue ACAP1 crystal structure of arfgap and ank repeat domain of acap1 2.3Å AUTH M.BAI,X.PANG,J.LOU,Q.ZHOU,K.ZHANG,J.MA,J.LI,F.SUN,V.W.HSUTITL MECHANISTIC INSIGHTS INTO REGULATED CARGO BINDING BY ACAP1TITL 2 PROTEINREF J.BIOL.CHEM. V. 287 28675 2012REFN ISSN 0021-9258PMID 22645133DOI 10.1074/JBC.M112.378810 Variant Set Distributions Mapped Variants
General Structure Information 2kkt ATXN7L3 solution structure of the sca7 domain of human ataxin-7-l3 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uvl BIRC3 human bir3 domain of baculoviral inhibitor of apoptosis repeat-containing 3 (birc3) 1.91Å AUTH M.D.HERMAN,M.MOCHE,S.FLODIN,M.WELIN,L.TRESAUGUES,AUTH 2 I.JOHANSSON,M.NILSSON,P.NORDLUND,T.NYMANTITL STRUCTURES OF BIR DOMAINS FROM HUMAN NAIP AND CIAP2.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1091 2009REFN ISSN 1744-3091PMID 19923725DOI 10.1107/S1744309109038597 Variant Set Distributions Mapped Variants
General Structure Information 2ro1 TRIM28 nmr solution structures of human kap1 phd finger-bromodomain -1.0Å AUTH L.ZENG,K.L.YAP,A.V.IVANOV,X.WANG,S.MUJTABA,AUTH 2 O.PLOTNIKOVA,F.J.RAUSCHER,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO HUMAN KAP1 PHDTITL 2 FINGER-BROMODOMAIN AND ITS ROLE IN GENE SILENCINGREF NAT.STRUCT.MOL.BIOL. V. 15 626 2008REFN ISSN 1545-9993PMID 18488044DOI 10.1038/NSMB.1416 Variant Set Distributions Mapped Variants
General Structure Information 3io2 EP300 crystal structure of the taz2 domain of p300 2.5Å AUTH M.MILLER,Z.DAUTER,S.CHERRY,J.E.TROPEA,A.WLODAWERTITL STRUCTURE OF THE TAZ2 DOMAIN OF P300: INSIGHTS INTO LIGANDTITL 2 BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 65 1301 2009REFN ISSN 0907-4449PMID 19966416DOI 10.1107/S0907444909040153 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jed PRKCQ the crystal structure of the kinase domain of the protein kinase c theta in complex with nvp-xaa228 at 2.32a resolution. 2.32Å AUTH W.STARK,F.BITSCH,A.BERNER,F.BUELENS,P.GRAFF,AUTH 2 H.DEPERSIN,G.FENDRICH,M.GEISER,R.KNECHT,J.RAHUEL,AUTH 3 G.RUMMEL,J.M.SCHLAEPPI,R.SCHMITZ,A.STRAUSS,J.WAGNERTITL THE CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF THETITL 2 PROTEIN KINASE C THETA IN COMPLEX WITH NVP-XAA228REF TO BE PUBLISHEDREFN Variant Set […]