Assessment of Structural Intolerance and Durability
General Structure Information 4lg8 PRPF19 crystal structure of prpf19 wd40 repeats 1.89Å AUTH C.XU,W.TEMPEL,H.HE,E.DOBROVETSKY,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MIN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i2n WDR92 crystal structure of wd40 repeats protein wdr92 1.95Å AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1 Variant Set Distributions Mapped Variants
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w18 PALB2 crystal structure of the c-terminal wd40 domain of human palb2 1.9Å AUTH A.W.OLIVER,S.SWIFT,C.J.LORD,A.ASHWORTH,L.H.PEARLTITL STRUCTURAL BASIS FOR RECRUITMENT OF BRCA2 BY PALB2REF EMBO REP. V. 10 990 2009REFN ISSN 1469-221XPMID 19609323DOI 10.1038/EMBOR.2009.126 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ggd CDC20 structural analysis of human cdc20 supports multisite degron recognition by apc/c. 2.44Å AUTH W.TIAN,B.LI,R.WARRINGTON,D.R.TOMCHICK,H.YU,X.LUOTITL STRUCTURAL ANALYSIS OF HUMAN CDC20 SUPPORTS MULTISITE DEGRONTITL 2 RECOGNITION BY APC/C.REF PROC.NATL.ACAD.SCI.USA V. 109 18419 2012REFN ISSN 0027-8424PMID 23091007DOI 10.1073/PNAS.1213438109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n6j STRN3 crystal structure of human striatin-3 coiled coil domain 2.0Å AUTH C.C.CHEN,Z.B.SHI,W.Q.ZHANG,M.CHEN,F.HE,Z.Z.ZHANG,Y.C.WANG,AUTH 2 M.FENG,W.J.WANG,Y.ZHAO,J.H.BROWN,S.JIAO,Z.C.ZHOUTITL STRIATINS CONTAIN A NONCANONICAL COILED COIL THAT BINDS PP2ATITL 2 A TO FORM A 2:2 HETEROTETRAMERIC CORE OFTITL 3 STRIATIN-INTERACTING PHOSPHATASE AND KINASE (STRIPAK)TITL 4 COMPLEXREF J.BIOL.CHEM. 2014REFN ESSN 1083-351XDOI 10.1074/JBC.M113.529297 Variant Set Distributions Mapped Variants
General Structure Information 2ce8 TLE1 an eh1 peptide bound to the groucho-tle wd40 domain. 2.03Å AUTH B.H.JENNINGS,L.M.PICKLES,S.M.WAINWRIGHT,S.M.ROE,L.H.PEARL,AUTH 2 D.ISH-HOROWICZTITL MOLECULAR RECOGNITION OF TRANSCRIPTIONAL REPRESSOR MOTIFSTITL 2 BY THE WD DOMAIN OF THE GROUCHO/TLE COREPRESSOR.REF MOL.CELL V. 22 645 2006REFN ISSN 1097-2765PMID 16762837DOI 10.1016/J.MOLCEL.2006.04.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4ggd CDC20 structural analysis of human cdc20 supports multisite degron recognition by apc/c. 2.44Å AUTH W.TIAN,B.LI,R.WARRINGTON,D.R.TOMCHICK,H.YU,X.LUOTITL STRUCTURAL ANALYSIS OF HUMAN CDC20 SUPPORTS MULTISITE DEGRONTITL 2 RECOGNITION BY APC/C.REF PROC.NATL.ACAD.SCI.USA V. 109 18419 2012REFN ISSN 0027-8424PMID 23091007DOI 10.1073/PNAS.1213438109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n6j STRN3 crystal structure of human striatin-3 coiled coil domain 2.0Å AUTH C.C.CHEN,Z.B.SHI,W.Q.ZHANG,M.CHEN,F.HE,Z.Z.ZHANG,Y.C.WANG,AUTH 2 M.FENG,W.J.WANG,Y.ZHAO,J.H.BROWN,S.JIAO,Z.C.ZHOUTITL STRIATINS CONTAIN A NONCANONICAL COILED COIL THAT BINDS PP2ATITL 2 A TO FORM A 2:2 HETEROTETRAMERIC CORE OFTITL 3 STRIATIN-INTERACTING PHOSPHATASE AND KINASE (STRIPAK)TITL 4 COMPLEXREF J.BIOL.CHEM. 2014REFN ESSN 1083-351XDOI 10.1074/JBC.M113.529297 Variant Set Distributions Mapped Variants
General Structure Information 2ce8 TLE1 an eh1 peptide bound to the groucho-tle wd40 domain. 2.03Å AUTH B.H.JENNINGS,L.M.PICKLES,S.M.WAINWRIGHT,S.M.ROE,L.H.PEARL,AUTH 2 D.ISH-HOROWICZTITL MOLECULAR RECOGNITION OF TRANSCRIPTIONAL REPRESSOR MOTIFSTITL 2 BY THE WD DOMAIN OF THE GROUCHO/TLE COREPRESSOR.REF MOL.CELL V. 22 645 2006REFN ISSN 1097-2765PMID 16762837DOI 10.1016/J.MOLCEL.2006.04.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]