Assessment of Structural Intolerance and Durability
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yn8 EPHB4 ephb4 kinase domain inhibitor complex 2.11Å AUTH R.C.OVERMAN,I.GREEN,C.M.TRUMAN,J.A.READ,K.J.EMBREY,AUTH 2 M.S.B.MCALISTER,T.K.ATTWOODTITL STABILITY AND SOLUBILITY ENGINEERING OF THE EPHB4 TYROSINETITL 2 KINASE CATALYTIC DOMAIN USING A RATIONALLY DESIGNEDTITL 3 SYNTHETIC LIBRARY.REF PROTEIN ENG.DES.SEL. V. 26 695 2013REFN ISSN 1741-0126PMID 23840071DOI 10.1093/PROTEIN/GZT032 Variant Set Distributions Mapped Variants