Assessment of Structural Intolerance and Durability
General Structure Information 3ldz STAM crystal structure of human stam1 vhs domain in complex with ubiquitin 2.6Å AUTH X.REN,J.H.HURLEYTITL VHS DOMAINS OF ESCRT-0 COOPERATE IN HIGH-AVIDITYTITL 2 BINDING TO POLYUBIQUITINATED CARGO.REF EMBO J. V. 29 1045 2010REFN ISSN 0261-4189PMID 20150893DOI 10.1038/EMBOJ.2010.6 Variant Set Distributions Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dqv CUL5 structural insights into nedd8 activation of cullin-ring ligases: conformational control of conjugation 3.0Å AUTH D.M.DUDA,L.A.BORG,D.C.SCOTT,H.W.HUNT,M.HAMMEL,AUTH 2 B.A.SCHULMANTITL STRUCTURAL INSIGHTS INTO NEDD8 ACTIVATION OFTITL 2 CULLIN-RING LIGASES: CONFORMATIONAL CONTROL OFTITL 3 CONJUGATION.REF CELL(CAMBRIDGE,MASS.) V. 134 995 2008REFN ISSN 0092-8674PMID 18805092DOI 10.1016/J.CELL.2008.07.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2yho MYLIP the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Mapped Variants
General Structure Information 2ylm USP7 mechanism of usp7 (hausp) activation by its c-terminal ubiquitin-like domain (hubl) and allosteric regulation by gmp-synthetase. 2.7Å AUTH A.C.FAESEN,A.M.G.DIRAC,A.SHANMUGHAM,H.OVAA,A.PERRAKIS,AUTH 2 T.K.SIXMATITL MECHANISM OF USP7/HAUSP ACTIVATION BY ITS C- TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN AND ALLOSTERIC REGULATION BYTITL 3 GMP-SYNTHETASEREF MOL.CELL V. 44 147 2011REFN ISSN 1097-2765PMID 21981925DOI 10.1016/J.MOLCEL.2011.06.034 Variant Set Distributions […]
General Structure Information 2nq3 ITCH crystal structure of the c2 domain of human itchy homolog e3 ubiquitin protein ligase 1.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL THE C2 DOMAIN OF HUMAN ITCHY HOMOLOG E3 UBIQUITINTITL 2 PROTEIN LIGASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2izv SOCS4 crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution 2.55Å AUTH A.N.BULLOCK,M.C.RODRIGUEZ,J.E.DEBRECZENI,Z.SONGYANG,S.KNAPPTITL STRUCTURE OF THE SOCS4-ELONGINB/C COMPLEX REVEALS ATITL 2 DISTINCT SOCS BOX INTERFACE AND THE MOLECULAR BASIS FORTITL 3 SOCS-DEPENDENT EGFR DEGRADATION.REF STRUCTURE V. 15 1493 2007REFN ISSN 0969-2126PMID 17997974DOI 10.1016/J.STR.2007.09.016 Variant Set Distributions Mapped […]
General Structure Information 3dl2 UEVLD hexagonal structure of the ldh domain of human ubiquitin- conjugating enzyme e2-like isoform a 2.1Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,E.M.NEWMAN,AUTH 2 P.J.FINERTY JR.,C.BUTLER-COLE,C.BOUNTRA,AUTH 3 M.WOLKSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL STRUCTURAL INVESTIGATION INTO THE L-LACTATETITL 2 DEHYDROGENASE DOMAIN OF HUMANTITL 3 UBIQUITIN-CONJUGATING ENZYME E2-LIKE ISOFORM A.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3icu RNF128 protease-associated domain of the e3 ligase grail 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL PA DOMAIN OF THE E3 LIGASE GRAILREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pg6 DTX3L the carboxyl terminal domain of human deltex 3-like 1.7Å AUTH J.OBIERO,J.R.WALKER,S.DHE-PAGANONTITL FOLD OF THE CONSERVED DTC DOMAIN IN DELTEX PROTEINS.REF PROTEINS V. 80 1495 2012REFN ISSN 0887-3585PMID 22411408DOI 10.1002/PROT.24054 Variant Set Distributions Mapped Variants