Assessment of Structural Intolerance and Durability
General Structure Information 3hu2 VCP structure of p97 n-d1 r86a mutant in complex with atpgs 2.85Å AUTH W.K.TANG,D.LI,C.C.LI,L.ESSER,R.DAI,L.GUO,D.XIATITL A NOVEL ATP-DEPENDENT CONFORMATION IN P97 N-D1 FRAGMENTTITL 2 REVEALED BY CRYSTAL STRUCTURES OF DISEASE-RELATED MUTANTS.REF EMBO J. V. 29 2217 2010REFN ISSN 0261-4189PMID 20512113DOI 10.1038/EMBOJ.2010.104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2cte HDLBP solution structure of the 1st kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gy5 NUTF2 d92n,d94n double point mutant of human nuclear transport factor 2 (ntf2) 2.3Å AUTH R.BAYLISS,S.LEUNG,R.BAKER,B.QUIMBY,A.CORBETT,AUTH 2 M.STEWARTTITL STRUCTURAL BASIS FOR THE INTERACTION BETWEEN NTF2TITL 2 AND NUCLEOPORIN FXFG REPEATSREF EMBO J. V. 21 2843 2002REFN ISSN 0261-4189PMID 12065398DOI 10.1093/EMBOJ/CDF305 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ctm HDLBP solution structure of the 14th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gzd RAB11A crystal structure of rab11 in complex with rab11-fip2 2.44Å AUTH W.N.JAGOE,A.J.LINDSAY,R.J.READ,A.J.MCCOY,AUTH 2 M.W.MCCAFFREY,A.R.KHANTITL CRYSTAL STRUCTURE OF RAB11 IN COMPLEX WITH RAB11TITL 2 FAMILY INTERACTING PROTEIN 2.REF STRUCTURE V. 14 1273 2006REFN ISSN 0969-2126PMID 16905101DOI 10.1016/J.STR.2006.06.010 Variant Set Distributions Mapped Variants
General Structure Information 3ajb PEX3 crystal structure of human pex3p in complex with n-terminal pex19p peptide 2.5Å AUTH Y.SATO,H.SHIBATA,T.NAKATSU,H.NAKANO,Y.KASHIWAYAMA,T.IMANAKA,AUTH 2 H.KATOTITL STRUCTURAL BASIS FOR DOCKING OF PEROXISOMAL MEMBRANE PROTEINTITL 2 CARRIER PEX19P ONTO ITS RECEPTOR PEX3PREF EMBO J. V. 29 4083 2010REFN ISSN 0261-4189PMID 21102411DOI 10.1038/EMBOJ.2010.293 Variant Set Distributions Mapped Variants
General Structure Information 2ovc KCNQ4 crystal structure of a coiled-coil tetramerization domain from kv7.4 channels 2.07Å AUTH R.J.HOWARD,K.A.CLARK,J.M.HOLTON,D.L.MINORTITL STRUCTURAL INSIGHT INTO KCNQ (KV7) CHANNEL ASSEMBLY ANDTITL 2 CHANNELOPATHY.REF NEURON V. 53 663 2007REFN ISSN 0896-6273PMID 17329207DOI 10.1016/J.NEURON.2007.02.010 Variant Set Distributions Mapped Variants
General Structure Information 3gd8 AQP4 crystal structure of human aquaporin 4 at 1.8 and its mechanism of conductance 1.8Å AUTH J.D.HO,R.YEH,A.SANDSTROM,I.CHORNY,W.E.HARRIES,R.A.ROBBINS,AUTH 2 L.J.MIERCKE,R.M.STROUDTITL CRYSTAL STRUCTURE OF HUMAN AQUAPORIN 4 AT 1.8 A AND ITSTITL 2 MECHANISM OF CONDUCTANCE.REF PROC.NATL.ACAD.SCI.USA V. 106 7437 2009REFN ISSN 0027-8424PMID 19383790DOI 10.1073/PNAS.0902725106 Variant Set Distributions Mapped Variants
General Structure Information 1yg5 HBA2 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]
General Structure Information 1yg5 HBA1 t-to-t(high) quaternary transitions in human hemoglobin: betaw37h oxy (2mm ihp, 20% peg) (10 test sets) 2.7Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONETITL CRYSTALLOGRAPHIC EVIDENCE FOR A NEW ENSEMBLE OFTITL 2 LIGAND-INDUCED ALLOSTERIC TRANSITIONS INTITL 3 HEMOGLOBIN: THE T-TO-T(HIGH) QUATERNARYTITL 4 TRANSITIONS.REF BIOCHEMISTRY V. 44 6101 2005REFN ISSN 0006-2960PMID 15835899DOI 10.1021/BI047813A Variant Set Distributions Pathogenic […]