Assessment of Structural Intolerance and Durability
General Structure Information 2b6h ARF5 structure of human adp-ribosylation factor 5 1.76Å AUTH A.ATANASSOVA,W.TEMPEL,E.SUNDARAJAN,S.DIMOV,I.SHEHAB,J.LEW,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hei RAB5B crystal structure of human rab5b in complex with gdp 1.55Å AUTH B.HONG,L.SHEN,J.WANG,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB5B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1i3d HBG1 human carbonmonoxy hemoglobin barts (gamma4) 1.7Å AUTH R.D.KIDD,H.M.BAKER,A.J.MATHEWS,T.BRITTAIN,E.N.BAKERTITL OLIGOMERIZATION AND LIGAND BINDING IN ATITL 2 HOMOTETRAMERIC HEMOGLOBIN: TWO HIGH-RESOLUTIONTITL 3 CRYSTAL STRUCTURES OF HEMOGLOBIN BARTSTITL 4 (GAMMA(4)), A MARKER FOR ALPHA-THALASSEMIA.REF PROTEIN SCI. V. 10 1739 2001REFN ISSN 0961-8368PMID 11514664DOI 10.1110/PS.11701 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4drz RAB14 crystal structure of human rab14 2.3Å AUTH J.WANG,W.TEMPEL,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3u0d LCN2 the structure of human siderocalin bound to the bacterial siderophore 2,3-dhba 2.51Å AUTH C.CORRENTI,V.RICHARDSON,A.K.SIA,A.D.BANDARANAYAKE,M.RUIZ,AUTH 2 Y.SURYO RAHMANTO,Z.KOVACEVIC,M.C.CLIFTON,M.A.HOLMES,AUTH 3 B.K.KAISER,J.BARASCH,K.N.RAYMOND,D.R.RICHARDSON,R.K.STRONGTITL SIDEROCALIN/LCN2/NGAL/24P3 DOES NOT DRIVE APOPTOSIS THROUGHTITL 2 GENTISIC ACID MEDIATED IRON WITHDRAWAL IN HEMATOPOIETIC CELLTITL 3 LINES.REF PLOS ONE V. 7 43696 2012REFN ESSN 1932-6203PMID 22928018DOI 10.1371/JOURNAL.PONE.0043696 Variant Set Distributions Mapped […]
General Structure Information 1xye HBB t-to-thigh transitions in human hemoglobin: alpha y42a deoxy low salt 2.13Å AUTH J.S.KAVANAUGH,P.H.ROGERS,A.ARNONE,H.L.HUI,AUTH 2 A.WIERZBA,A.DEYOUNG,L.D.KWIATKOWSKI,R.W.NOBLE,AUTH 3 L.J.JUSZCZAK,E.S.PETERSON,J.M.FRIEDMANTITL INTERSUBUNIT INTERACTIONS ASSOCIATED WITHTITL 2 TYR42ALPHA STABILIZE THE QUATERNARY-T TETRAMER BUTTITL 3 ARE NOT MAJOR QUATERNARY CONSTRAINTS INTITL 4 DEOXYHEMOGLOBINREF BIOCHEMISTRY V. 44 3806 2005REFN ISSN 0006-2960PMID 15751957DOI 10.1021/BI0484670 Variant Set Distributions Ripley’s […]
General Structure Information 3nwv CYCS human cytochrome c g41s 1.9Å AUTH M.D.LIPTAK,R.D.FAGERLUND,E.C.LEDGERWOOD,S.M.WILBANKS,AUTH 2 K.L.BRENTITL THE PROAPOPTOTIC G41S MUTATION TO HUMAN CYTOCHROME C ALTERSTITL 2 THE HEME ELECTRONIC STRUCTURE AND INCREASES THE ELECTRONTITL 3 SELF-EXCHANGE RATE.REF J.AM.CHEM.SOC. V. 133 1153 2011REFN ISSN 0002-7863PMID 21192676DOI 10.1021/JA106328K Variant Set Distributions Mapped Variants
General Structure Information 2ctj HDLBP solution structure of the 8th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 8TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uw5 PITPNA structure of pitp-alpha complexed to phosphatidylinositol 2.9Å AUTH S.J.TILLEY,A.SKIPPEN,J.MURRAY-RUST,P.M.SWIGART,AUTH 2 A.STEWART,C.P.MORGAN,S.COCKCROFT,N.Q.MCDONALDTITL STRUCTURE-FUNCTION ANALYSIS OF HUMAN [CORRECTED]TITL 2 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA BOUNDTITL 3 TO PHOSPHATIDYLINOSITOL.REF STRUCTURE V. 12 317 2004REFN ISSN 0969-2126PMID 14962392DOI 10.1016/J.STR.2004.01.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tso RAB25 structure of the cancer associated rab25 protein in complex with fip2 1.8Å AUTH S.ODA,P.Y.LALL,M.W.MCCAFFREY,A.R.KHANTITL STRUCTURE OF THE CANCER ASSOCIATED RAB25 PROTEIN IN COMPLEXTITL 2 WITH FIP2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants