Assessment of Structural Intolerance and Durability
General Structure Information 2k60 STIM1 nmr structure of calcium-loaded stim1 ef-sam -1.0Å AUTH P.B.STATHOPULOS,L.ZHENG,G.Y.LI,M.J.PLEVIN,M.IKURATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO STIM1-MEDIATEDTITL 2 INITIATION OF STORE-OPERATED CALCIUM ENTRY.REF CELL(CAMBRIDGE,MASS.) V. 135 110 2008REFN ISSN 0092-8674PMID 18854159DOI 10.1016/J.CELL.2008.08.006 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h8m EPHA7 sam domain of human ephrin type-a receptor 7 (epha7) 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rei EPHA7 kinase domain of human ephrin type-a receptor 7 (epha7) 1.6Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bbt ERBB4 crystal structure of the erbb4 kinase in complex with lapatinib 2.8Å AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hrn PKD2 crystal structure of a c-terminal coiled coil domain of transient receptor potential (trp) channel subfamily p member 2 (trpp2, polycystic kidney disease 2) 1.9Å AUTH Y.YU,M.H.ULBRICH,M.H.LI,Z.BURAEI,X.Z.CHEN,A.C.ONG,AUTH 2 L.TONG,E.Y.ISACOFF,J.YANGTITL STRUCTURAL AND MOLECULAR BASIS OF THE ASSEMBLY OFTITL 2 THE TRPP2/PKD1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 106 11558 2009REFN ISSN 0027-8424PMID 19556541DOI 10.1073/PNAS.0903684106 Variant […]
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2z7x TLR1 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2c7s PTPRK crystal structure of human protein tyrosine phosphatase kappa at 1.95a resolution 1.95Å AUTH J.ESWARAN,J.E.DEBRECZENI,E.LONGMAN,A.BARR,S.KNAPPTITL THE CRYSTAL STRUCTURE OF HUMAN RECEPTOR PROTEIN TYROSINETITL 2 KAPPA PHOSPHATASE KAPPA DOMAIN 1.REF PROTEIN SCI. V. 15 1500 2006REFN ISSN 0961-8368PMID 16672235DOI 10.1110/PS.062128706 Variant Set Distributions Mapped Variants
General Structure Information 2kij ATP7A solution structure of the actuator domain of the copper- transporting atpase atp7a -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,G.NATILE,AUTH 2 F.NUSHI,A.ROSATOTITL SOLUTION STRUCTURES OF THE ACTUATOR DOMAIN OF ATP7ATITL 2 AND ATP7B, THE MENKES AND WILSON DISEASE PROTEINSREF BIOCHEMISTRY V. 48 7849 2009REFN ISSN 0006-2960PMID 19645496DOI 10.1021/BI901003K Variant Set Distributions Mapped Variants