Assessment of Structural Intolerance and Durability
General Structure Information 3kka EPHA1 co-crystal structure of the sam domains of epha1 and epha2 2.4Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CO-CRYSTAL STRUCTURE OF THE SAM DOMAINS OF HUMANTITL 2 EPHRIN TYPE-A RECEPTOR 1 AND HUMAN EPHRIN TYPE-ATITL 3 RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3jxh PTPRG ca-like domain of human ptprg 1.7Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k4t VDAC1 solution structure of human vdac-1 in ldao micelles -1.0Å AUTH S.HILLER,R.G.GARCES,T.J.MALIA,V.Y.OREKHOV,AUTH 2 M.COLOMBINI,G.WAGNERTITL SOLUTION STRUCTURE OF THE INTEGRAL HUMAN MEMBRANETITL 2 PROTEIN VDAC-1 IN DETERGENT MICELLES.REF SCIENCE V. 321 1206 2008REFN ISSN 0036-8075PMID 18755977DOI 10.1126/SCIENCE.1161302 Variant Set Distributions Mapped Variants
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bpo IL4R crystal structure of the il13-il4r-il13ra ternary complex 3.0Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qon EPHA3 human epha3 kinase and juxtamembrane region, y596f:y602f:y742a triple mutant 1.79Å AUTH T.L.DAVIS,J.R.WALKER,P.LOPPNAU,C.BUTLER-COLE,AUTH 2 A.ALLALI-HASSANI,S.DHE-PAGANONTITL AUTOREGULATION BY THE JUXTAMEMBRANE REGION OF THE HUMANTITL 2 EPHRIN RECEPTOR TYROSINE KINASE A3 (EPHA3).REF STRUCTURE V. 16 873 2008REFN ISSN 0969-2126PMID 18547520DOI 10.1016/J.STR.2008.03.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2zw3 GJB2 structure of the connexin-26 gap junction channel at 3.5 angstrom resolution 3.5Å AUTH S.MAEDA,S.NAKAGAWA,M.SUGA,E.YAMASHITA,A.OSHIMA,AUTH 2 Y.FUJIYOSHI,T.TSUKIHARATITL STRUCTURE OF THE CONNEXIN 26 GAP JUNCTION CHANNELTITL 2 AT 3.5 A RESOLUTIONREF NATURE V. 458 597 2009REFN ISSN 0028-0836PMID 19340074DOI 10.1038/NATURE07869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3kul EPHA8 kinase domain of human ephrin type-a receptor 8 (epha8) 2.15Å AUTH J.R.WALKER,L.YERMEKBAYEVA,J.KANIA,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 8 (EPHA8)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v60 MAOB structure of human mao b in complex with the selective inhibitor 7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin 2.0Å AUTH C.BINDA,J.WANG,L.PISANI,C.CACCIA,A.CAROTTI,AUTH 2 P.SALVATI,D.E.EDMONDSON,A.MATTEVITITL STRUCTURES OF HUMAN MONOAMINE OXIDASE B COMPLEXESTITL 2 WITH SELECTIVE NONCOVALENT INHIBITORS: SAFINAMIDETITL 3 AND COUMARIN ANALOGS.REF J.MED.CHEM. V. 50 5848 2007REFN ISSN 0022-2623PMID 17915852DOI 10.1021/JM070677Y Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2k8o ITGAL solution structure of integrin alpha l -1.0Å AUTH A.BHUNIA,X.-Y.TANG,H.MOHANRAM,S.-M.TAN,AUTH 2 S.BHATTACHARJYATITL NMR SOLUTION CONFORMATIONS AND INTERACTIONS OFTITL 2 INTEGRIN {ALPHA}L{BETA}2 CYTOPLASMIC TAILSREF J.BIOL.CHEM. V. 284 3873 2009REFN ISSN 0021-9258PMID 19073598DOI 10.1074/JBC.M807236200 Variant Set Distributions Mapped Variants