Assessment of Structural Intolerance and Durability
General Structure Information 4kzx EIF1 rabbit 40s ribosomal subunit in complex with eif1. 7.81Å AUTH I.B.LOMAKIN,T.A.STEITZTITL THE INITIATION OF MAMMALIAN PROTEIN SYNTHESIS AND MRNATITL 2 SCANNING MECHANISM.REF NATURE V. 500 307 2013REFN ISSN 0028-0836PMID 23873042DOI 10.1038/NATURE12355 Variant Set Distributions Mapped Variants
General Structure Information 2j76 EIF4B solution structure and rna interactions of the rna recognition motif from eukaryotic translation initiation factor 4b -1.0Å AUTH K.FLEMING,J.GHUMAN,X.M.YUAN,P.SIMPSON,A.SZENDROI,AUTH 2 S.MATTHEWS,S.CURRYTITL SOLUTION STRUCTURE AND RNA INTERACTIONS OF THE RNATITL 2 RECOGNITION MOTIF FROM EUKARYOTIC TRANSLATIONTITL 3 INITIATION FACTOR 4B.REF BIOCHEMISTRY V. 42 8966 2003REFN ISSN 0006-2960PMID 12885229DOI 10.1021/BI034506G Variant Set […]
General Structure Information 3tf2 EIF4E crystal structure of the cap free human translation initiation factor eif4e 2.1Å AUTH N.SIDDIQUI,W.TEMPEL,L.NEDYALKOVA,L.VOLPON,A.K.WERNIMONT,AUTH 2 M.J.OSBORNE,H.W.PARK,K.L.BORDENTITL STRUCTURAL INSIGHTS INTO THE ALLOSTERIC EFFECTS OF 4EBP1 ONTITL 2 THE EUKARYOTIC TRANSLATION INITIATION FACTOR EIF4E.REF J.MOL.BIOL. V. 415 781 2012REFN ISSN 0022-2836PMID 22178476DOI 10.1016/J.JMB.2011.12.002 Variant Set Distributions Mapped Variants
General Structure Information 1q8k EIF2S1 solution structure of alpha subunit of human eif2 -1.0Å AUTH T.ITO,A.MARINTCHEV,G.WAGNERTITL SOLUTION STRUCTURE OF HUMAN INITIATION FACTORTITL 2 EIF2ALPHA REVEALS HOMOLOGY TO THE ELONGATIONTITL 3 FACTOR EEF1B.REF STRUCTURE V. 12 1693 2004REFN ISSN 0969-2126PMID 15341733DOI 10.1016/J.STR.2004.07.010 Variant Set Distributions Mapped Variants
General Structure Information 3zjy IPO13 crystal structure of importin 13 – rangtp – eif1a complex 3.6Å AUTH M.GRUNWALD,D.LAZZARETTI,F.BONOTITL STRUCTURAL BASIS FOR THE NUCLEAR EXPORT ACTIVITY OFTITL 2 IMPORTIN13.REF EMBO J. V. 32 899 2013REFN ISSN 0261-4189PMID 23435562DOI 10.1038/EMBOJ.2013.29 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bpj EIF3J crystal structure of human translation initiation factor 3, subunit 1 alpha 1.85Å AUTH L.NEDYALKOVA,B.HONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN TRANSLATION INITIATION FACTOR 3,TITL 2 SUBUNIT 1 ALPHA.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jgc EIF4E2 structure of the human eif4e homologous protein, 4ehp without ligand bound 2.4Å AUTH P.ROSETTANI,S.KNAPP,M.G.VISMARA,L.RUSCONI,AUTH 2 A.D.CAMERONTITL STRUCTURES OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN,TITL 2 H4EHP, IN ITS M(7)GTP-BOUND AND UNLIGANDED FORMS.REF J.MOL.BIOL. V. 368 691 2007REFN ISSN 0022-2836PMID 17368478DOI 10.1016/J.JMB.2007.02.019 Variant Set Distributions Mapped Variants
General Structure Information 1hu3 EIF4G3 middle domain of human eif4gii 2.37Å AUTH J.MARCOTRIGIANO,I.B.LOMAKIN,N.SONENBERG,AUTH 2 T.V.PESTOVA,C.U.HELLEN,S.K.BURLEYTITL A CONSERVED HEAT DOMAIN WITHIN EIF4G DIRECTSTITL 2 ASSEMBLY OF THE TRANSLATION INITIATION MACHINERY.REF MOL.CELL V. 7 193 2001REFN ISSN 1097-2765PMID 11172724DOI 10.1016/S1097-2765(01)00167-8 Variant Set Distributions Mapped Variants
General Structure Information 2hyi CASC3 structure of the human exon junction complex with a trapped dead-box helicase bound to rna 2.3Å AUTH C.B.F.ANDERSEN,L.BALLUT,J.S.JOHANSEN,H.CHAMIEH,AUTH 2 K.H.NIELSEN,C.L.OLIVEIRA,J.S.PEDERSEN,B.SERAPHIN,AUTH 3 H.LE HIR,G.R.ANDERSENTITL STRUCTURE OF THE EXON JUNCTION CORE COMPLEX WITH ATITL 2 TRAPPED DEAD-BOX ATPASE BOUND TO RNA.REF SCIENCE V. 313 1968 2006REFN ISSN 0036-8075PMID 16931718DOI 10.1126/SCIENCE.1131981 Variant Set […]