Assessment of Structural Intolerance and Durability
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l6a EIF4G2 crystal structure of the c-terminal region of human p97 2.0Å AUTH S.FAN,M.JIA,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMANTITL 2 P97/DAP5REF PROTEINS 2010REFN ESSN 1097-0134DOI 10.1002/PROT.22735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nlw EIF3B solution structure of the rrm domain of human eukaryotic initiation factor 3b -1.0Å AUTH L.ELANTAK,A.G.TZAKOS,N.LOCKER,P.J.LUKAVSKYTITL STRUCTURE OF EIF3B RNA RECOGNITION MOTIF AND ITSTITL 2 INTERACTION WITH EIF3J: STRUCTURAL INSIGHTS INTOTITL 3 THE RECRUITMENT OF EIF3B TO THE 40 S RIBOSOMALTITL 4 SUBUNIT.REF J.BIOL.CHEM. V. 282 8165 2007REFN ISSN 0021-9258PMID 17190833DOI […]
General Structure Information 2g2k EIF5 nmr structure of an n-terminal fragment of the eukaryotic initiation factor 5 (eif5) -1.0Å AUTH M.R.CONTE,G.KELLY,J.BABON,D.SANFELICE,J.YOUELL,AUTH 2 S.J.SMERDON,C.G.PROUDTITL STRUCTURE OF THE EUKARYOTIC INITIATION FACTORTITL 2 (EIF) 5 REVEALS A FOLD COMMON TO SEVERALTITL 3 TRANSLATION FACTORSREF BIOCHEMISTRY V. 45 4550 2006REFN ISSN 0006-2960PMID 16584190DOI 10.1021/BI052387U Variant Set Distributions Mapped Variants
General Structure Information 1h95 YBX1 solution structure of the single-stranded dna-binding cold shock domain (csd) of human y-box protein 1 (yb1) determined by nmr (10 lowest energy structures) -1.0Å AUTH C.P.A.M.KLOKS,C.A.E.M.SPRONK,E.LASONDER,A.HOFFMANN,AUTH 2 G.W.VUISTER,S.GRZESIEK,C.W.HILBERSTITL THE SOLUTION STRUCTURE AND DNA-BINDING PROPERTIESTITL 2 OF THE COLD-SHOCK DOMAIN OF THE HUMAN Y-BOXTITL 3 PROTEIN YB-1.REF J.MOL.BIOL. V. 316 317 […]
General Structure Information 4iul EIF4G2 mif4g domain of dap5 2.3Å AUTH G.VIRGILI,F.FRANK,K.FEOKTISTOVA,M.SAWICKI,N.SONENBERG,AUTH 2 C.S.FRASER,B.NAGARTITL STRUCTURAL ANALYSIS OF THE DAP5 MIF4G DOMAIN AND ITSTITL 2 INTERACTION WITH EIF4A.REF STRUCTURE V. 21 517 2013REFN ISSN 0969-2126PMID 23478064DOI 10.1016/J.STR.2013.01.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2iu1 EIF5 crystal structure of eif5 c-terminal domain 1.8Å AUTH C.BIENIOSSEK,P.SCHUTZ,M.BUMANN,A.LIMACHER,I.USON,AUTH 2 U.BAUMANNTITL THE CRYSTAL STRUCTURE OF THE CARBOXY-TERMINALTITL 2 DOMAIN OF HUMAN TRANSLATION INITIATION FACTORTITL 3 EIF5.REF J.MOL.BIOL. V. 360 457 2006REFN ISSN 0022-2836PMID 16781736DOI 10.1016/J.JMB.2006.05.021 Variant Set Distributions Mapped Variants
General Structure Information 3e1y ETF1 crystal structure of human erf1/erf3 complex 3.8Å AUTH Z.CHENG,K.SAITO,A.V.PISAREV,M.WADA,V.P.PISAREVA,T.V.PESTOVA,AUTH 2 M.GAJDA,A.ROUND,C.KONG,M.LIM,Y.NAKAMURA,D.I.SVERGUN,K.ITO,AUTH 3 H.SONGTITL STRUCTURAL INSIGHTS INTO ERF3 AND STOP CODON RECOGNITION BYTITL 2 ERF1REF GENES DEV. V. 23 1106 2009REFN ISSN 0890-9369PMID 19417105DOI 10.1101/GAD.1770109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 1oni HRSP12 crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the yjgf/uk114 protein family 1.9Å AUTH B.A.MANJASETTY,H.DELBRUCK,D.T.PHAM,U.MUELLER,AUTH 2 M.FIEBER-ERDMANN,C.SCHEICH,V.SIEVERT,K.BUSSOW,F.H.NIESEN,AUTH 3 W.WEIHOFEN,B.LOLL,W.SAENGER,U.HEINEMANN,F.H.NEISENTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PROTEIN HP14.5.REF PROTEINS V. 54 797 2004REFN ISSN 0887-3585PMID 14997576DOI 10.1002/PROT.10619 Variant Set Distributions […]