Assessment of Structural Intolerance and Durability
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1aww BTK sh3 domain from brutons tyrosine kinase, nmr, 42 structures -1.0Å AUTH H.HANSSON,P.T.MATTSSON,P.ALLARD,P.HAAPANIEMI,AUTH 2 M.VIHINEN,C.I.SMITH,T.HARDTITL SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM BRUTONSTITL 2 TYROSINE KINASE.REF BIOCHEMISTRY V. 37 2912 1998REFN ISSN 0006-2960PMID 9485443DOI 10.1021/BI972409F Variant Set Distributions Mapped Variants
General Structure Information 2ge9 BTK solution structures of the sh2 domain of brutons tyrosine kinase -1.0Å AUTH K.-C.HUANG,H.-T.CHENG,M.-T.PAI,S.-R.TZENG,AUTH 2 J.-W.CHENGTITL SOLUTION STRUCTURE AND PHOSPHOPEPTIDE BINDING OFTITL 2 THE SH2 DOMAIN FROM THE HUMAN BRUTONS TYROSINETITL 3 KINASEREF J.BIOMOL.NMR V. 36 73 2006REFN ISSN 0925-2738PMID 16969585DOI 10.1007/S10858-006-9064-3 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k2p BTK crystal structure of brutons tyrosine kinase domain 2.1Å AUTH C.MAO,M.ZHOU,F.M.UCKUNTITL CRYSTAL STRUCTURE OF BRUTONS TYROSINE KINASETITL 2 DOMAIN SUGGESTS A NOVEL PATHWAY FOR ACTIVATION ANDTITL 3 PROVIDES INSIGHTS INTO THE MOLECULAR BASIS OFTITL 4 X-LINKED AGAMMAGLOBULINEMIA.REF J.BIOL.CHEM. V. 276 41435 2001REFN ISSN 0021-9258PMID 11527964DOI 10.1074/JBC.M104828200 Variant Set Distributions Ripley’s K […]
General Structure Information 2vd5 DMPK structure of human myotonic dystrophy protein kinase in complex with the bisindoylmaleide inhibitor bim viii 2.8Å AUTH J.ELKINS,A.AMOS,F.NIESEN,A.C.W.PIKE,O.FEDOROV,S.KNAPPTITL STRUCTURE OF DYSTROPHIA MYOTONICA PROTEIN KINASE.REF PROTEIN SCI. V. 18 782 2009REFN ISSN 0961-8368PMID 19309729DOI 10.1002/PRO.82 Variant Set Distributions Mapped Variants
General Structure Information 4ckr DDR1 crystal structure of the human ddr1 kinase domain in complex with ddr1-in-1 2.2Å AUTH H.KIM,L.TAN,E.L.WEISBERG,F.LIU,P.CANNING,H.G.CHOI,S.A.EZELL,AUTH 2 H.WU,Z.ZHAO,J.WANG,A.MANDINOVA,J.D.GRIFFIN,A.N.BULLOCK,AUTH 3 Q.LIU,S.W.LEE,N.S.GRAYTITL DISCOVERY OF A POTENT AND SELECTIVE DDR1 RECEPTOR TYROSINETITL 2 KINASE INHIBITOR.REF ACS CHEM.BIOL. V. 8 2145 2013REFN ISSN 1554-8929PMID 23899692DOI 10.1021/CB400430T Variant Set Distributions Mapped Variants
General Structure Information 3kuc RAP1A complex of rap1a(e30d/k31e)gdp with rafrbd(a85k/n71r) 1.92Å AUTH D.FILCHTINSKI,O.SHARABI,A.RUPPEL,I.R.VETTER,C.HERRMANN,AUTH 2 J.M.SHIFMANTITL WHAT MAKES RAS AN EFFICIENT MOLECULAR SWITCH: ATITL 2 COMPUTATIONAL, BIOPHYSICAL, AND STRUCTURAL STUDY OF RAS-GDPTITL 3 INTERACTIONS WITH MUTANTS OF RAF.REF J.MOL.BIOL. V. 399 422 2010REFN ISSN 0022-2836PMID 20361980DOI 10.1016/J.JMB.2010.03.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2obv MAT1A crystal structure of the human s-adenosylmethionine synthetase 1 in complex with the product 2.05Å AUTH E.S.PILKA,N.SHAFQAT,K.L.KAVANAGH,C.COOPER,V.HOZJAN,AUTH 2 A.TURNBULL,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 3 M.SUNDSTROM,U.OPPERMANN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINETITL 2 SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]
General Structure Information 3dlx OXCT1 crystal structure of human 3-oxoacid coa transferase 1 2.2Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.W.YUE,S.PICAUD,J.W.MURRAY,AUTH 2 E.M.MACLEAN,F.VON DELFT,A.K.ROOS,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-OXOACID COA TRANSFERASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants