Assessment of Structural Intolerance and Durability
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ifs SSRP1 crystal structure of the hssrp1 middle domain 1.93Å AUTH W.J.ZHANG,F.X.ZENG,C.SHAO,Y.W.LIU,L.W.NIU,X.LI,M.K.TENGTITL CRYSTAL STRUCTURE OF THE HSSRP1 MIDDLE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f6n BPTF crystal structure of phd finger-linker-bromodomain fragment of human bptf in the free form 2.0Å AUTH H.LI,S.ILIN,W.WANG,E.M.DUNCAN,J.WYSOCKA,C.D.ALLIS,AUTH 2 D.J.PATELTITL MOLECULAR BASIS FOR SITE-SPECIFIC READ-OUT OFTITL 2 HISTONE H3K4ME3 BY THE BPTF PHD FINGER OF NURF.REF NATURE V. 442 91 2006REFN ISSN 0028-0836PMID 16728978DOI 10.1038/NATURE04802 Variant Set Distributions Mapped Variants
General Structure Information 2l33 ILF3 solution nmr structure of drbm 2 domain of interleukin enhancer- binding factor 3 from homo sapiens, northeast structural genomics consortium target hr4527e -1.0Å AUTH G.LIU,H.JANJUA,R.XIAO,T.B.ACTON,J.EVERETT,G.T.MONTELIONETITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4527EREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lvu ZBTB17 solution structure of miz-1 zinc finger 10 -1.0Å AUTH M.BEDARD,L.MALTAIS,M.E.BEAULIEU,J.BILODEAU,D.BERNARD,AUTH 2 P.LAVIGNETITL NMR STRUCTURE NOTE: SOLUTION STRUCTURE OF HUMAN MIZ-1 ZINCTITL 2 FINGERS 8 TO 10.REF J.BIOMOL.NMR V. 54 317 2012REFN ISSN 0925-2738PMID 22986688DOI 10.1007/S10858-012-9670-1 Variant Set Distributions Mapped Variants
General Structure Information 2j2s KMT2A solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone methyltransferase -1.0Å AUTH M.D.ALLEN,C.G.GRUMMITT,C.HILCENKO,S.Y.MIN,AUTH 2 L.M.TONKIN,C.M.JOHNSON,S.M.FREUND,M.BYCROFT,AUTH 3 A.J.WARRENTITL SOLUTION STRUCTURE OF THE NONMETHYL-CPG-BINDINGTITL 2 CXXC DOMAIN OF THE LEUKAEMIA-ASSOCIATED MLLTITL 3 HISTONE METHYLTRANSFERASEREF EMBO J. V. 25 4503 2006REFN ISSN 0261-4189PMID 16990798DOI 10.1038/SJ.EMBOJ.7601340 Variant Set Distributions Mapped Variants
General Structure Information 1ljm RUNX1 dna recognition is mediated by conformational transition and by dna bending 2.5Å AUTH D.BARTFELD,L.SHIMON,G.COUTURE,D.RABINOVICH,AUTH 2 F.FROLOW,D.LEVANON,Y.GRONER,Z.SHAKKEDTITL DNA RECOGNITION BY THE RUNX1 TRANSCRIPTION FACTORTITL 2 IS MEDIATED BY AN ALLOSTERIC TRANSITION IN THETITL 3 RUNT DOMAIN AND BY DNA BENDING.REF STRUCTURE V. 10 1395REFN ISSN 0969-2126PMID 12377125DOI 10.1016/S0969-2126(02)00853-5 Variant Set Distributions […]
General Structure Information 1zdt NR5A1 the crystal structure of human steroidogenic factor-1 2.1Å AUTH W.WANG,C.ZHANG,A.MARIMUTHU,H.I.KRUPKA,M.TABRIZIZAD,AUTH 2 R.SHELLOE,U.MEHRA,K.ENG,H.NGUYEN,C.SETTACHATGUL,B.POWELL,AUTH 3 M.V.MILBURN,B.L.WESTTITL THE CRYSTAL STRUCTURES OF HUMAN STEROIDOGENIC FACTOR-1 ANDTITL 2 LIVER RECEPTOR HOMOLOGUE-1REF PROC.NATL.ACAD.SCI.USA V. 102 7505 2005REFN ISSN 0027-8424PMID 15897460DOI 10.1073/PNAS.0409482102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants