General Structure Information
| PDB ID | 1ljm |
| HGNC Gene Label(s) | RUNX1 |
| Structure Name | dna recognition is mediated by conformational transition and by dna bending |
| Resolution | 2.5Å |
| Reference | AUTH D.BARTFELD,L.SHIMON,G.COUTURE,D.RABINOVICH,AUTH 2 F.FROLOW,D.LEVANON,Y.GRONER,Z.SHAKKEDTITL DNA RECOGNITION BY THE RUNX1 TRANSCRIPTION FACTORTITL 2 IS MEDIATED BY AN ALLOSTERIC TRANSITION IN THETITL 3 RUNT DOMAIN AND BY DNA BENDING.REF STRUCTURE V. 10 1395REFN ISSN 0969-2126PMID 12377125DOI 10.1016/S0969-2126(02)00853-5 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 114 |
| Number Of SNVs | 12 |
| Number Of Permutations | 1142 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.227 |
| p-value | 0.624 |
ClinVar
| Number Of Residues | 114 |
| Number Of SNVs | 5 |
| Number Of Permutations | 357 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.0 |
| p-value | 0.051 |
COSMIC
| Number Of Residues | 114 |
| Number Of SNVs | 20 |
| Number Of Permutations | 2090 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.5 |
| p-value | 0.005 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.197 |
| p-value | 0.108 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.352 |
| p-value | 0.031 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
