Assessment of Structural Intolerance and Durability
General Structure Information 2qw4 NR4A1 human nr4a1 ligand-binding domain 2.8Å AUTH J.R.MIN,A.SCHUETZ,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN NR4A1 LIGAND-BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jxj KDM5A nmr structure of the arid domain from the histone h3k4 demethylase rbp2 -1.0Å AUTH S.TU,Y.C.TENG,C.YUAN,Y.T.WU,M.Y.CHAN,A.N.CHENG,AUTH 2 P.H.LIN,L.J.JUAN,M.D.TSAITITL THE ARID DOMAIN OF THE H3K4 DEMETHYLASE RBP2 BINDSTITL 2 TO A DNA CCGCCC MOTIFREF NAT.STRUCT.MOL.BIOL. V. 15 419 2008REFN ISSN 1545-9993PMID 18270511DOI 10.1038/NSMB.1400 Variant Set Distributions Mapped Variants
General Structure Information 3cmy PAX3 structure of a homeodomain in complex with dna 1.95Å AUTH G.BIRRANE,A.SONI,J.A.LADIASTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY THE HUMAN PAX3TITL 2 HOMEODOMAIN.REF BIOCHEMISTRY V. 48 1148 2009REFN ISSN 0006-2960PMID 19199574DOI 10.1021/BI802052Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bbb NME2 crystal structure of the nm23-h2 transcription factor complex with dinucleotide d(ag) 1.3Å AUTH T.S.DEXHEIMER,S.S.CAREY,S.ZUOHE,V.M.GOKHALE,X.HU,L.B.MURATA,AUTH 2 E.M.MAES,A.WEICHSEL,D.SUN,E.J.MEUILLET,W.R.MONTFORT,AUTH 3 L.H.HURLEYTITL NM23-H2 MAY PLAY AN INDIRECT ROLE IN TRANSCRIPTIONALTITL 2 ACTIVATION OF C-MYC GENE EXPRESSION BUT DOES NOT CLEAVE THETITL 3 NUCLEASE HYPERSENSITIVE ELEMENT III1.REF MOL.CANCER THER. V. 8 1363 2009REFN ISSN 1535-7163PMID […]
General Structure Information 1bor PML transcription factor pml, a proto-oncoprotein, nmr, 1 representative structure at ph 7.5, 30 c, in the presence of zinc -1.0Å AUTH K.L.BORDEN,M.N.BODDY,J.LALLY,N.J.OREILLY,S.MARTIN,AUTH 2 K.HOWE,E.SOLOMON,P.S.FREEMONTTITL THE SOLUTION STRUCTURE OF THE RING FINGER DOMAINTITL 2 FROM THE ACUTE PROMYELOCYTIC LEUKAEMIATITL 3 PROTO-ONCOPROTEIN PML.REF EMBO J. V. 14 1532 1995REFN ISSN 0261-4189PMID 7729428 […]
General Structure Information 3f1p ARNT crystal structure of a high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains 1.17Å AUTH T.H.SCHEUERMANN,D.R.TOMCHICK,M.MACHIUS,Y.GUO,AUTH 2 R.K.BRUICK,K.H.GARDNERTITL ARTIFICIAL LIGAND BINDING WITHIN THE HIF2ALPHATITL 2 PAS-B DOMAIN OF THE HIF2 TRANSCRIPTION FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 106 450 2009REFN ISSN 0027-8424PMID 19129502DOI 10.1073/PNAS.0808092106 Variant Set Distributions Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1svc NFKB1 nfkb p50 homodimer bound to dna 2.6Å AUTH C.W.MULLER,F.A.REY,M.SODEOKA,G.L.VERDINE,AUTH 2 S.C.HARRISONTITL STRUCTURE OF THE NF-KAPPA B P50 HOMODIMER BOUND TOTITL 2 DNA.REF NATURE V. 373 311 1995REFN ISSN 0028-0836PMID 7830764DOI 10.1038/373311A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dzu RXRA intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide 3.2Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3lhr ZNF24 crystal structure of the scan domain from human znf24 1.9Å AUTH B.F.VOLKMAN,F.C.PETERSON,C.A.BINGMAN,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE SCAN DOMAIN FROM HUMAN ZNF24REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants