Assessment of Structural Intolerance and Durability
General Structure Information 1t3g IL1RAPL1 crystal structure of the toll/interleukin-1 receptor (tir) domain of human il-1rapl 2.3Å AUTH J.A.KHAN,E.K.BRINT,L.A.J.ONEILL,L.TONGTITL CRYSTAL STRUCTURE OF THE TOLL/INTERLEUKIN-1TITL 2 RECEPTOR DOMAIN OF HUMAN IL-1RAPLREF J.BIOL.CHEM. V. 279 31664 2004REFN ISSN 0021-9258PMID 15123616DOI 10.1074/JBC.M403434200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2j67 TLR10 the tir domain of human toll-like receptor 10 (tlr10) 2.2Å AUTH T.NYMAN,P.STENMARK,S.FLODIN,I.JOHANSSON,M.HAMMARSTROM,AUTH 2 P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF THE HUMAN TOLL-LIKE RECEPTOR 10TITL 2 CYTOPLASMIC DOMAIN REVEALS A PUTATIVE SIGNALING DIMER.REF J.BIOL.CHEM. V. 283 11861 2008REFN ISSN 0021-9258PMID 18332149DOI 10.1074/JBC.C800001200 Variant Set Distributions Mapped Variants
General Structure Information 2m1x TICAM1 ticam-1 tir domain structure -1.0Å AUTH Y.ENOKIZONO,H.KUMETA,K.FUNAMI,M.HORIUCHI,J.SARMIENTO,AUTH 2 K.YAMASHITA,D.M.STANDLEY,M.MATSUMOTO,T.SEYA,F.INAGAKITITL STRUCTURES AND INTERFACE MAPPING OF THE TIRTITL 2 DOMAIN-CONTAINING ADAPTOR MOLECULES INVOLVED IN INTERFERONTITL 3 SIGNALING.REF PROC.NATL.ACAD.SCI.USA V. 110 19908 2013REFN ISSN 0027-8424PMID 24255114DOI 10.1073/PNAS.1222811110 Variant Set Distributions Mapped Variants
General Structure Information 2m1w TICAM2 ticam-2 tir domain -1.0Å AUTH Y.ENOKIZONO,H.KUMETA,K.FUNAMI,M.HORIUCHI,J.SARMIENTO,AUTH 2 K.YAMASHITA,D.M.STANDLEY,M.MATSUMOTO,T.SEYA,F.INAGAKITITL STRUCTURES AND INTERFACE MAPPING OF THE TIRTITL 2 DOMAIN-CONTAINING ADAPTOR MOLECULES INVOLVED IN INTERFERONTITL 3 SIGNALING.REF PROC.NATL.ACAD.SCI.USA V. 110 19908 2013REFN ISSN 0027-8424PMID 24255114DOI 10.1073/PNAS.1222811110 Variant Set Distributions Mapped Variants
General Structure Information 3ub2 TIRAP tir domain of mal/tirap 2.4Å AUTH Z.LIN,J.LU,W.ZHOU,Y.SHENTITL STRUCTURAL INSIGHTS INTO TIR DOMAIN SPECIFICITY OF THETITL 2 BRIDGING ADAPTOR MAL IN TLR4 SIGNALINGREF PLOS ONE V. 7 34202 2012REFN ESSN 1932-6203PMID 22485159DOI 10.1371/JOURNAL.PONE.0034202 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ub2 TIRAP tir domain of mal/tirap 2.4Å AUTH Z.LIN,J.LU,W.ZHOU,Y.SHENTITL STRUCTURAL INSIGHTS INTO TIR DOMAIN SPECIFICITY OF THETITL 2 BRIDGING ADAPTOR MAL IN TLR4 SIGNALINGREF PLOS ONE V. 7 34202 2012REFN ESSN 1932-6203PMID 22485159DOI 10.1371/JOURNAL.PONE.0034202 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants