Assessment of Structural Intolerance and Durability
General Structure Information 2c0y CTSS the crystal structure of a cys25ala mutant of human procathepsin s 2.1Å AUTH G.KAULMANN,G.J.PALM,K.SCHILLING,R.HILGENFELD,AUTH 2 B.WIEDERANDERSTITL THE CRYSTAL STRUCTURE OF A CYS25 -> ALA MUTANT OFTITL 2 HUMAN PROCATHEPSIN S ELUCIDATES ENZYME-PROSEQUENCETITL 3 INTERACTIONS.REF PROTEIN SCI. V. 15 2619 2006REFN ISSN 0961-8368PMID 17075137DOI 10.1110/PS.062401806 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1zcm CAPN1 human calpain protease core inhibited by zllych2f 2.0Å AUTH Q.LI,R.P.HANZLIK,R.F.WEAVER,E.SCHONBRUNNTITL MOLECULAR MODE OF ACTION OF A COVALENTLYTITL 2 INHIBITING PEPTIDOMIMETIC ON THE HUMAN CALPAINTITL 3 PROTEASE COREREF BIOCHEMISTRY V. 45 701 2006REFN ISSN 0006-2960PMID 16411745DOI 10.1021/BI052077B Variant Set Distributions Mapped Variants
General Structure Information 1gmy CTSB cathepsin b complexed with dipeptidyl nitrile inhibitor 1.9Å AUTH P.D.GREENSPAN,K.L.CLARK,R.A.TOMMASI,S.D.COWEN,AUTH 2 L.W.MCQUIRE,D.L.FARLEY,J.H.VAN DUZER,R.L.GOLDBERG,AUTH 3 H.ZHOU,Z.DU,J.J.FITT,D.E.COPPA,Z.FANG,W.MACCHIA,AUTH 4 L.ZHU,M.P.CAPPARELLI,R.GOLDSTEIN,A.M.WIGG,AUTH 5 J.R.DOUGHTY,R.S BOHACEK,A.K.KNAPTITL IDENTIFICATION OF DIPEPTIDYL NITRILES AS POTENTTITL 2 AND SELECTIVE INHIBITORS OF CATHEPSIN B THROUGHTITL 3 STRUCTURE-BASED DRUG DESIGNREF J.MED.CHEM. V. 44 4524 2001REFN ISSN 0022-2623PMID 11741472DOI 10.1021/JM010206Q Variant Set Distributions […]
General Structure Information 3kfq CTSV unreduced cathepsin v in complex with stefin a 1.99Å AUTH M.RENKO,D.TURKTITL UNREDUCED CATHEPSIN V IN COMPLEX WITH STEFIN AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h11 CFLAR zymogen caspase-8:c-flipl protease domain complex 1.9Å AUTH J.W.YU,P.D.JEFFREY,Y.SHITITL MECHANISM OF PROCASPASE-8 ACTIVATION BY C-FLIPL.REF PROC.NATL.ACAD.SCI.USA V. 106 8169 2009REFN ISSN 0027-8424PMID 19416807DOI 10.1073/PNAS.0812453106 Variant Set Distributions Mapped Variants