Assessment of Structural Intolerance and Durability
General Structure Information 2dh7 TIAL1 solution structure of the second rna binding domain in nucleolysin tiar -1.0Å AUTH T.IMAI,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA BINDINGTITL 2 DOMAIN IN NUCLEOLYSIN TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ct2 TRIM32 solution structure of the ring domain of the tripartite motif protein 32 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THETITL 2 TRIPARTITE MOTIF PROTEIN 32REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dt7 SF3A3 solution structure of the second surp domain of human splicing factor sf3a120 in complex with a fragment of human splicing factor sf3a60 -1.0Å AUTH K.KUWASAKO,F.HE,M.INOUE,A.TANAKA,S.SUGANO,AUTH 2 P.GUENTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SURP DOMAINS AND THETITL 2 SUBUNIT-ASSEMBLY MECHANISM WITHIN THE SPLICINGTITL 3 FACTOR SF3A COMPLEX IN 17S U2 SNRNPREF STRUCTURE […]
General Structure Information 2enz PRKCQ solution structure of the second c1 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND C1 DOMAIN FROMTITL 2 HUMAN PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ha8 TARBP1 methyltransferase domain of human tar (hiv-1) rna binding protein 1 1.6Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,K.BATTAILE,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1 INTITL 3 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cud SLA solution structure of the sh3 domain of the human src-like adopter protein (slap) -1.0Å AUTH S.OHNISHI,T.KIGAWA,N.TOCHIO,M.SATO,N.NAMEKI,AUTH 2 S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 SRC-LIKE ADOPTER PROTEIN (SLAP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3nf1 KLC1 crystal structure of the tpr domain of kinesin light chain 1 2.8Å AUTH Y.TONG,W.TEMPEL,L.SHEN,Y.SHEN,L.NEDYALKOVA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE TPR DOMAIN OF KINESIN LIGHT CHAIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1yb5 CRYZ crystal structure of human zeta-crystallin with bound nadp 1.85Å AUTH J.DEBRECZENI,G.BERRIDGE,K.KAVANAGH,S.COLBROOK,J.BRAY,AUTH 2 L.WILLIAMS,U.OPPERMANN,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF HUMAN ZETA-CRYSTALLIN AT 1.85AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wch PTPN13 crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer – evidence for a second phosphotyrosine substrate recognition pocket 1.85Å AUTH F.VILLA,M.DEAK,G.B.BLOOMBERG,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF PTPL1/FAP-1 HUMAN TYROSINETITL 2 PHOSPHATASE MUTATED IN COLORECTAL CANCER:TITL 3 EVEIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATETITL 4 RECOGNITION POCKETREF J.BIOL.CHEM. V. […]