Assessment of Structural Intolerance and Durability
General Structure Information 4mtl METTL21C human methyltransferase-like protein 21c 1.65Å AUTH B.S.HONG,W.TEMPEL,A.DONG,Y.LI,C.H.ARROWSMITH,C.BOUNTRA,AUTH 2 A.M.EDWARDS,P.J.BROWNTITL HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1uhc DNMBP solution structure of rsgi ruh-002, a sh3 domain of kiaa1010 protein [homo sapiens] -1.0Å AUTH T.ABE,H.HIROTA,N.KOBAYASHI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-002, A SH3 DOMAINTITL 2 OF KIAA1010 PROTEIN [HOMO SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q3h RHOU the crystal structure of rhoua in the gdp-bound state. 1.73Å AUTH C.GILEADI,X.YANG,E.PAPAGRIGORIOU,J.ELKINS,Y.ZHAO,J.BRAY,AUTH 2 O.GILEADI,C.UMEANO,E.UGOCHUKWU,J.UPPENBERG,G.BUNKOCZI,AUTH 3 F.VON DELFT,A.C.W.PIKE,C.PHILLIPS,P.SAVITSKY,O.FEDOROV,AUTH 4 A.EDWARDS,J.WEIGELT,C.H.ARROWSMITH,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF RHOUA IN THE GDP-BOUND STATE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i7a CAPN13 domain iv of human calpain 13 1.8Å AUTH J.R.WALKER,K.NG,T.L.DAVIS,R.RAVULAPALLI,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,E.M.NEWMAN,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN CALPAIN 13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2da1 ZFHX3 solution structure of the first homeobox domain of at- binding transcription factor 1 (atbf1) -1.0Å AUTH S.OHNISHI,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST HOMEOBOX DOMAIN OFTITL 2 AT-BINDING TRANSCRIPTION FACTOR 1 (ATBF1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wjr SFMBT2 solution structure of the 2nd mbt domain from human kiaa1617 protein -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND MBT DOMAIN FROMTITL 2 HUMAN KIAA1617 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2g59 PTPRO crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens 2.19Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ebq DESI1 crystal structure of human pppde1 1.9Å AUTH J.R.WALKER,M.AKUTSU,L.QIU,Y.LI,Y.SLESSAREV,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN PPPDE1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants