Assessment of Structural Intolerance and Durability
General Structure Information 2f7s RAB27B the crystal structure of human rab27b bound to gdp 2.7Å AUTH J.WANG,S.ISMAIL,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL THE CRYSTAL STRUCTURE OF HUMAN RAB27BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z3k NCK2 structural insight into the binding diversity between the tyr-phosphorylated human ephrinbs and nck2 sh2 domain -1.0Å AUTH X.RAN,J.SONGTITL STRUCTURAL INSIGHT INTO THE BINDING DIVERSITYTITL 2 BETWEEN THE TYR-PHOSPHORYLATED HUMAN EPHRINBS ANDTITL 3 NCK2 SH2 DOMAIN.REF J.BIOL.CHEM. V. 280 19205 2005REFN ISSN 0021-9258PMID 15764601DOI 10.1074/JBC.M500330200 Variant Set Distributions Mapped Variants
General Structure Information 2fim TULP1 structure of the c-terminal domain of human tubby-like protein 1 1.9Å AUTH C.PERSSON,D.OGG,A.G.THORSELL,C.ARROWSMITH,H.BERGLUND,AUTH 2 A.EDWARDS,M.EHN,S.FLODIN,S.GRASLUND,M.HAMMARSTROM,M.HOGBOM,AUTH 3 L.HOLMBERG-SCHIAVONE,T.KOTENYOVA,P.KURSULA,P.NILSSON-EHLE,AUTH 4 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 5 S.VAN DEN BERG,J.WEIGELT,B.M.HALLBERGTITL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKETITL 2 PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ihb RGS10 crystal structure of the heterodimeric complex of human rgs10 and activated gi alpha 3 2.71Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 2dls ARHGEF11 solution structure of the pdz domain of human rho guanine nucleotide exchange factor 11 -1.0Å AUTH K.INOUE,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOTITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR 11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dmg ESYT2 solution structure of the third c2 domain of kiaa1228 protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD C2 DOMAIN OFTITL 2 KIAA1228 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2do3 SUPT5H solution structure of the third kow motif of transcription elongation factor spt5 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD KOW MOTIF OFTITL 2 TRANSCRIPTION ELONGATION FACTOR SPT5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d9k TRAFD1 solution structure of the zf-traf domain of fln29 gene product -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-TRAF DOMAIN OF FLN29TITL 2 GENE PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cru PDCD5 solution structure of programmed cell death 5 -1.0Å AUTH T.NAGASHIMA,K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF PROGRAMMED CELL DEATH 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c8b RIPK2 structure of the kinase domain of human ripk2 in complex with ponatinib 2.75Å AUTH P.CANNING,A.BULLOCKTITL STRUCTURE OF THE KINASE DOMAIN OF HUMAN RIPK2 IN COMPLEXTITL 2 WITH PONATINIBREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants