Assessment of Structural Intolerance and Durability
General Structure Information 3op3 CDC25C crystal structure of cell division cycle 25c protein isoform a from homo sapiens 2.63Å AUTH Y.KIM,A.WEGER,C.HATZOS,P.SAVITSKY,C.JOHANSSON,L.BALL,A.BARR,AUTH 2 M.VOLLMAR,J.MUNIZ,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,O.GILEADI,F.VON DELFT,S.KNAPP,A.JOACHIMIAKTITL CRYSTAL STRUCTURE OF CELL DIVISION CYCLE 25C PROTEIN ISOFORMTITL 2 A FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qon EPHA3 human epha3 kinase and juxtamembrane region, y596f:y602f:y742a triple mutant 1.79Å AUTH T.L.DAVIS,J.R.WALKER,P.LOPPNAU,C.BUTLER-COLE,AUTH 2 A.ALLALI-HASSANI,S.DHE-PAGANONTITL AUTOREGULATION BY THE JUXTAMEMBRANE REGION OF THE HUMANTITL 2 EPHRIN RECEPTOR TYROSINE KINASE A3 (EPHA3).REF STRUCTURE V. 16 873 2008REFN ISSN 0969-2126PMID 18547520DOI 10.1016/J.STR.2008.03.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2hw5 ECHS1 the crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1 2.55Å AUTH A.P.TURNBULL,E.SALAH,F.NIESEN,J.DEBRECZENI,E.UGOCHUKWU,AUTH 2 A.C.W.PIKE,K.KAVANAGH,O.GILEADI,F.GORREC,C.UMEANO,AUTH 3 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 4 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ENOYL-COENZYME A (COA)TITL 2 HYDRATASE SHORT CHAIN 1, ECHS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1x4b HNRNPA2B1 solution structure of rrm domain in heterogeneous nuclear ribonucleaoproteins a2/b1 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RRM DOMAIN IN HETEROGENEOUSTITL 2 NUCLEAR RIBONUCLEAOPROTEINS A2/B1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qk3 CRYBB3 crystal structure of human beta-crystallin b3 1.95Å Variant Set Distributions Mapped Variants
General Structure Information 3sn5 CYP7A1 crystal structure of human cyp7a1 in complex with cholest-4-en-3-one 2.75Å AUTH N.STRUSHKEVICH,W.TEMPEL,F.MACKENZIE,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CYP7A1 IN COMPLEX WITHTITL 2 CHOLEST-4-EN-3-ONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ar7 AK4 crystal structure of human adenylate kinase 4, ak4 2.15Å AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,O.FEDOROV,J.WEIGELT,AUTH 2 G.BUNKOCZI,E.UGOCHUKWU,J.DEBRECZENI,F.NIESEN,F.VON DELFT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN ADENYLATE KINASE 4, AK4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dlh PTPRD solution structure of the second fn3 domain of human receptor-type tyrosine-protein phosphatase delta -1.0Å AUTH K.SEIMIYA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASETITL 3 DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1wwt TARS solution structure of the tgs domain from human threonyl- trna synthetase -1.0Å AUTH E.CHIKAYAMA,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TGS DOMAIN FROM HUMANTITL 2 THREONYL-TRNA SYNTHETASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants