Assessment of Structural Intolerance and Durability
General Structure Information 3hzj RABGAP1L crystal structure of the rabgap domain of the rabgap1l protein 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THETITL 2 RABGAP1L PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rpp MBNL2 solution structure of tandem zinc finger domain 12 in muscleblind-like protein 2 -1.0Å AUTH F.HE,W.DANG,C.ABE,K.TSUDA,M.INOUE,S.WATANABE,AUTH 2 N.KOBAYASHI,T.KIGAWA,T.MATSUDA,T.YABUKI,M.AOKI,AUTH 3 E.SEKI,T.HARADA,Y.TOMABECHI,T.TERADA,M.SHIROUZU,AUTH 4 A.TANAKA,P.GUNTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN INTITL 2 THE HUMAN MUSCLEBLIND-LIKE PROTEIN 2REF PROTEIN SCI. V. 18 80 2009REFN ISSN 0961-8368PMID 19177353DOI 10.1002/PRO.17 Variant Set Distributions Mapped Variants
General Structure Information 3e1r CEP55 midbody targeting of the escrt machinery by a non-canonical coiled-coil in cep55 2.0Å AUTH H.H.LEE,N.ELIA,R.GHIRLANDO,J.LIPPINCOTT-SCHWARTZ,AUTH 2 J.H.HURLEYTITL MIDBODY TARGETING OF THE ESCRT MACHINERY BY ATITL 2 NONCANONICAL COILED COIL IN CEP55.REF SCIENCE V. 322 576 2008REFN ISSN 0036-8075PMID 18948538DOI 10.1126/SCIENCE.1162042 Variant Set Distributions Mapped Variants
General Structure Information 2c52 NCOA1 structural diversity in cbp p160 complexes -1.0Å AUTH L.C.WATERS,B.YUE,V.VEVERKA,P.S.RENSHAW,J.BRAMHAM,AUTH 2 S.MATSUDA,T.FRENKIEL,G.KELLY,F.W.MUSKETT,M.D.CARR,AUTH 3 D.M.HEERYTITL STRUCTURAL DIVERSITY IN P160/CREB-BINDING PROTEINTITL 2 COACTIVATOR COMPLEXES.REF J.BIOL.CHEM. V. 281 14787 2006REFN ISSN 0021-9258PMID 16540468DOI 10.1074/JBC.M600237200 Variant Set Distributions Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2khn ITSN1 nmr solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target hr3646e. -1.0Å AUTH J.L.MILLS,A.GHOSH,E.GARCIA,Q.ZHANG,R.SHASTRY,AUTH 2 E.L.FOOTE,H.JANJUA,T.B.ACTON,R.XIAO,J.K.EVERETT,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL NMR SOLUTION STRUCTURE OF THE EH 1 DOMAIN FROMTITL 2 HUMAN INTERSECTIN-1 PROTEIN. NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR3646E.REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 1jvg UAP1 crystal structure of human agx2 complexed with udpgalnac 2.3Å AUTH C.PENEFF,P.FERRARI,V.CHARRIER,Y.TABURET,C.MONNIER,AUTH 2 V.ZAMBONI,J.WINTER,M.HARNOIS,F.FASSY,Y.BOURNETITL CRYSTAL STRUCTURES OF TWO HUMAN PYROPHOSPHORYLASETITL 2 ISOFORMS IN COMPLEXES WITH UDPGLC(GAL)NAC: ROLE OFTITL 3 THE ALTERNATIVELY SPLICED INSERT IN THE ENZYMETITL 4 OLIGOMERIC ASSEMBLY AND ACTIVE SITE ARCHITECTURE.REF EMBO J. V. 20 6191 2001REFN ISSN 0261-4189PMID […]
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 3e9l PRPF8 crystal structure of human prp8, residues 1755-2016 1.95Å AUTH V.PENA,A.ROZOV,P.FABRIZIO,R.LUHRMANN,M.C.WAHLTITL STRUCTURE AND FUNCTION OF AN RNASE H DOMAIN AT THE HEART OFTITL 2 THE SPLICEOSOME.REF EMBO J. V. 27 2929 2008REFN ISSN 0261-4189PMID 18843295DOI 10.1038/EMBOJ.2008.209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants