General Structure Information 2gtp RGS1 crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1 2.55Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K […]
General Structure Information 4bgg ACVR1 crystal structure of the acvr1 kinase in complex with ldn-213844 2.56Å AUTH A.H.MOHEDAS,Y.WANG,C.E.SANVITALE,P.CANNING,S.CHOI,X.XING,AUTH 2 A.N.BULLOCK,G.D.CUNY,P.B.YUTITL STRUCTURE-ACTIVITY RELATIONSHIP OF 3,5-DIARYL-2-TITL 2 AMINOPYRIDINE ALK2 INHIBITORS REVEALS UNALTERED BINDINGTITL 3 AFFINITY FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA CAUSINGTITL 4 MUTANTS.REF J.MED.CHEM. V. 57 7900 2014REFN ISSN 0022-2623PMID 25101911DOI 10.1021/JM501177W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bgg ACVR1 crystal structure of the acvr1 kinase in complex with ldn-213844 2.56Å AUTH A.H.MOHEDAS,Y.WANG,C.E.SANVITALE,P.CANNING,S.CHOI,X.XING,AUTH 2 A.N.BULLOCK,G.D.CUNY,P.B.YUTITL STRUCTURE-ACTIVITY RELATIONSHIP OF 3,5-DIARYL-2-TITL 2 AMINOPYRIDINE ALK2 INHIBITORS REVEALS UNALTERED BINDINGTITL 3 AFFINITY FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA CAUSINGTITL 4 MUTANTS.REF J.MED.CHEM. V. 57 7900 2014REFN ISSN 0022-2623PMID 25101911DOI 10.1021/JM501177W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2wcb S100A12 s100a12 complex with zinc in the absence of calcium 1.73Å AUTH O.V.MOROZ,E.V.BLAGOVA,A.J.WILKINSON,K.S.WILSON,I.B.BRONSTEINTITL THE CRYSTAL STRUCTURES OF HUMAN S100A12 IN APO FORM AND INTITL 2 COMPLEX WITH ZINC: NEW INSIGHTS INTO S100A12TITL 3 OLIGOMERISATION.REF J.MOL.BIOL. V. 391 536 2009REFN ISSN 0022-2836PMID 19501594DOI 10.1016/J.JMB.2009.06.004 Variant Set Distributions Mapped Variants
General Structure Information 2ybx PIP4K2A crystal structure of human phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 2.56Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,S.GRASLUND,AUTH 3 T.KARLBERG,T.KOTENYOVA,E.KOUZNETSOVA,T.NYMAN,C.PERSSON,AUTH 4 H.SCHULER,M.I.SIPONEN,A.G.THORSELL,E.WAHLBERG,J.WEIGELT,AUTH 5 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHATIDYLINOSITOL-5-TITL 2 PHOSPHATE 4-KINASE TYPE-2 ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k5y CRHR1 crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 2.98Å AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3n9v INPP5B crystal structure of inpp5b 2.65Å AUTH L.TRESAUGUES,C.SILVANDER,S.FLODIN,M.WELIN,T.NYMAN,AUTH 2 S.GRASLUND,M.HAMMARSTROM,H.BERGLUND,P.NORDLUNDTITL STRUCTURAL BASIS FOR PHOSPHOINOSITIDE SUBSTRATE RECOGNITION,TITL 2 CATALYSIS, AND MEMBRANE INTERACTIONS IN HUMAN INOSITOLTITL 3 POLYPHOSPHATE 5-PHOSPHATASESREF STRUCTURE V. 22 744 2014REFN ISSN 0969-2126PMID 24704254DOI 10.1016/J.STR.2014.01.013 Variant Set Distributions Mapped Variants
General Structure Information 1bd9 PEBP1 human phosphatidylethanolamine binding protein 2.05Å AUTH M.J.BANFIELD,J.J.BARKER,A.C.PERRY,R.L.BRADYTITL FUNCTION FROM STRUCTURE? THE CRYSTAL STRUCTURE OFTITL 2 HUMAN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEINTITL 3 SUGGESTS A ROLE IN MEMBRANE SIGNAL TRANSDUCTION.REF STRUCTURE V. 6 1245 1998REFN ISSN 0969-2126PMID 9782050DOI 10.1016/S0969-2126(98)00125-7 Variant Set Distributions Mapped Variants