Assessment of Structural Intolerance and Durability
General Structure Information 2lfe HECW2 solution nmr structure of n-terminal domain of human e3 ubiquitin- protein ligase hecw2, northeast structural genomics consortium (nesg) target ht6306a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,S.CHITAYAT,S.DHE-PAGANON,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF N-TERMINAL DOMAIN OF E3 LIGASETITL 2 HECW2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dyo DNPEP crystal structure of human aspartyl aminopeptidase (dnpep) in complex with aspartic acid hydroxamate 2.2Å AUTH A.CHAIKUAD,E.S.PILKA,A.D.RISO,F.V.DELFT,K.L.KAVANAGH,AUTH 2 C.VENIEN-BRYAN,U.OPPERMANN,W.W.YUETITL STRUCTURE OF HUMAN ASPARTYL AMINOPEPTIDASE COMPLEXED WITHTITL 2 SUBSTRATE ANALOGUE: INSIGHT INTO CATALYTIC MECHANISM,TITL 3 SUBSTRATE SPECIFICITY AND M18 PEPTIDASE FAMILY.REF BMC STRUCT.BIOL. V. 12 14 2012REFN ESSN 1472-6807PMID 22720794DOI 10.1186/1472-6807-12-14 Variant […]
General Structure Information 3qmc CXXC1 structural basis of selective binding of nonmethylated cpg islands by the cxxc domain of cfp1 2.1Å AUTH C.XU,C.BIAN,R.LAM,A.DONG,J.MINTITL THE STRUCTURAL BASIS FOR SELECTIVE BINDING OF NON-METHYLATEDTITL 2 CPG ISLANDS BY THE CFP1 CXXC DOMAIN.REF NAT COMMUN V. 2 227 2011REFN ESSN 2041-1723PMID 21407193DOI 10.1038/NCOMMS1237 Variant Set Distributions Mapped Variants
General Structure Information 3mqi EBF1 human early b-cell factor 1 (ebf1) ipt/tig domain 2.3Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]
General Structure Information 3ckk METTL1 crystal structure of human methyltransferase-like protein 1 1.55Å AUTH H.ZENG,A.DONG,E.DOBROVETSKY,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3c5c RASL12 crystal structure of human ras-like, family 12 protein in complex with gdp 1.85Å AUTH L.SHEN,Y.TONG,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12TITL 2 PROTEIN IN COMPLEX WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pfs BRPF3 pwwp domain of human bromodomain and phd finger-containing protein 3 1.9Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Mapped Variants
General Structure Information 2f57 PAK7 crystal structure of the human p21-activated kinase 5 1.8Å AUTH J.ESWARAN,W.H.LEE,J.E.DEBRECZENI,P.FILIPPAKOPOULOS,AUTH 2 A.TURNBULL,O.FEDOROV,S.W.DEACON,J.R.PETERSON,S.KNAPPTITL CRYSTAL STRUCTURES OF THE P21-ACTIVATED KINASES PAK4, PAK5,TITL 2 AND PAK6 REVEAL CATALYTIC DOMAIN PLASTICITY OF ACTIVE GROUPTITL 3 II PAKS.REF STRUCTURE V. 15 201 2007REFN ISSN 0969-2126PMID 17292838DOI 10.1016/J.STR.2007.01.001 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3qwe GMIP crystal structure of the n-terminal domain of the gem interacting protein 2.4Å AUTH X.GUAN,W.TEMPEL,Y.TONG,L.SHEN,H.WANG,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE GEMTITL 2 INTERACTING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]