Assessment of Structural Intolerance and Durability
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 4gmj CNOT7 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2i7t CPSF3 structure of human cpsf-73 2.1Å AUTH C.R.MANDEL,S.KANEKO,H.ZHANG,D.GEBAUER,V.VETHANTHAM,AUTH 2 J.L.MANLEY,L.TONGTITL POLYADENYLATION FACTOR CPSF-73 IS THE PRE-MRNATITL 2 3-END-PROCESSING ENDONUCLEASE.REF NATURE V. 444 953 2006REFN ISSN 0028-0836PMID 17128255DOI 10.1038/NATURE05363 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wf1 RALY solution structure of rrm domain in rna-binding protein np_057951 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF RRM DOMAIN IN RNA-BINDINGTITL 2 PROTEIN NP_057951REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3krm IGF2BP1 imp1 kh34 2.75Å AUTH J.A.CHAO,Y.PATSKOVSKY,V.PATEL,M.LEVY,S.C.ALMO,AUTH 2 R.H.SINGERTITL ZBP1 RECOGNITION OF BETA-ACTIN ZIPCODE INDUCES RNATITL 2 LOOPING.REF GENES DEV. V. 24 148 2010REFN ISSN 0890-9369PMID 20080952DOI 10.1101/GAD.1862910 Variant Set Distributions Mapped Variants
General Structure Information 2oxc DDX20 human dead-box rna helicase ddx20, dead domain in complex with adp 1.3Å AUTH T.KARLBERG,D.OGG,C.H ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,B.M.HALLBERG,AUTH 4 M.HAMMARSTROM,M.HOGBOM,I.JOHANSSON,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,AUTH 6 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,A.G.THORSELL,AUTH 7 S.VAN DEN BERG,J.WEIGELT,L.HOLMBERG-SCHIAVONETITL HUMAN DEAD-BOX RNA HELICASE DDX20REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4cq1 PTBP2 crystal structure of the neuronal isoform of ptb 1.69Å AUTH A.JOSHI,V.ESTEVE,A.N.BUCKROYD,M.BLATTER,F.H.-T.ALLAIN,AUTH 2 S.CURRYTITL SOLUTION AND CRYSTAL STRUCTURES OF A C TERMINAL FRAGMENT OFTITL 2 THE NEURONAL ISOFORM OF THE POLYPYRIMIDINE TRACT BINDINGTITL 3 PROTEIN (NPTB)REF PEERJ V. 2 E211 2014REFN ISSN 2167-8359DOI 10.7287/PEERJ.PREPRINTS.211V1 Variant Set Distributions Mapped Variants
General Structure Information 1ft8 NXF1 crystal structure of the rna-binding domain of the mrna export factor tap 3.15Å AUTH E.LIKER,E.FERNANDEZ,E.IZAURRALDE,E.CONTITITL THE STRUCTURE OF THE MRNA EXPORT FACTOR TAPTITL 2 REVEALS A CIS ARRANGEMENT OF A NON-CANONICAL RNPTITL 3 DOMAIN AND AN LRR DOMAIN.REF EMBO J. V. 19 5587 2000REFN ISSN 0261-4189PMID 11060011DOI 10.1093/EMBOJ/19.21.5587 Variant Set […]
General Structure Information 2err RBFOX1 nmr structure of the rna binding domain of human fox-1 in complex with ugcaugu -1.0Å AUTH S.D.AUWETER,R.FASAN,L.REYMOND,J.G.UNDERWOOD,AUTH 2 D.L.BLACK,S.PITSCH,F.H.ALLAINTITL MOLECULAR BASIS OF RNA RECOGNITION BY THE HUMANTITL 2 ALTERNATIVE SPLICING FACTOR FOX-1.REF EMBO J. V. 25 163 2006REFN ISSN 0261-4189PMID 16362037DOI 10.1038/SJ.EMBOJ.7600918 Variant Set Distributions Ripley’s K Analysis Plots Variant […]