Assessment of Structural Intolerance and Durability
General Structure Information 2eap LCP2 solution structure of the n-terminal sam-domain of human lymphocyte cytosolic protein 2 -1.0Å AUTH A.K.GORONCY,M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,AUTH 2 T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL SAM-DOMAIN OFTITL 2 HUMAN LYMPHOCYTE CYTOSOLIC PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ro1 TRIM28 nmr solution structures of human kap1 phd finger-bromodomain -1.0Å AUTH L.ZENG,K.L.YAP,A.V.IVANOV,X.WANG,S.MUJTABA,AUTH 2 O.PLOTNIKOVA,F.J.RAUSCHER,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO HUMAN KAP1 PHDTITL 2 FINGER-BROMODOMAIN AND ITS ROLE IN GENE SILENCINGREF NAT.STRUCT.MOL.BIOL. V. 15 626 2008REFN ISSN 1545-9993PMID 18488044DOI 10.1038/NSMB.1416 Variant Set Distributions Mapped Variants
General Structure Information 3io2 EP300 crystal structure of the taz2 domain of p300 2.5Å AUTH M.MILLER,Z.DAUTER,S.CHERRY,J.E.TROPEA,A.WLODAWERTITL STRUCTURE OF THE TAZ2 DOMAIN OF P300: INSIGHTS INTO LIGANDTITL 2 BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 65 1301 2009REFN ISSN 0907-4449PMID 19966416DOI 10.1107/S0907444909040153 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 3g73 FOXM1 structure of the foxm1 dna binding 2.21Å AUTH D.R.LITTLER,M.ALVAREZ-FERNANDEZ,A.STEIN,R.G.HIBBERT,AUTH 2 T.HEIDEBRECHT,P.ALOY,R.H.MEDEMA,A.PERRAKISTITL STRUCTURE OF THE FOXM1 DNA-RECOGNITION DOMAIN BOUND TO ATITL 2 PROMOTER SEQUENCEREF NUCLEIC ACIDS RES. 2010REFN ESSN 1362-4962PMID 20360045DOI 10.1093/NAR/GKQ194 Variant Set Distributions Mapped Variants
General Structure Information 3gwx PPARD molecular recognition of fatty acids by peroxisome proliferator-activated receptors 2.4Å AUTH H.E.XU,M.H.LAMBERT,V.G.MONTANA,D.J.PARKS,AUTH 2 S.G.BLANCHARD,P.J.BROWN,D.D.STERNBACH,J.M.LEHMANN,AUTH 3 G.B.WISELY,T.M.WILLSON,S.A.KLIEWER,M.V.MILBURNTITL MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOMETITL 2 PROLIFERATOR-ACTIVATED RECEPTORS.REF MOL.CELL V. 3 397 1999REFN ISSN 1097-2765PMID 10198642DOI 10.1016/S1097-2765(00)80467-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qpw PRDM2 methyltransferase domain of human pr domain-containing protein 2 1.79Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]