Assessment of Structural Intolerance and Durability
General Structure Information 3d1n POU6F1 structure of human brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter 2.51Å AUTH J.H.PEREIRA,S.H.KIMTITL STRUCTURE OF HUMAN BRN-5 TRANSCRIPTION FACTOR INTITL 2 COMPLEX WITH CRH GENE PROMOTER.REF J.STRUCT.BIOL. V. 167 159 2009REFN ISSN 1047-8477PMID 19450691DOI 10.1016/J.JSB.2009.05.003 Variant Set Distributions Mapped Variants
General Structure Information 3a77 IRF3 the crystal structure of phosphorylated irf-3 1.8Å AUTH K.TAKAHASI,M.HORIUCHI,K.FUJII,S.NAKAMURA,N.N.NODA,AUTH 2 M.YONEYAMA,T.FUJITA,F.INAGAKITITL SER386 PHOSPHORYLATION OF TRANSCRIPTION FACTOR IRF-3 INDUCESTITL 2 DIMERIZATION AND ASSOCIATION WITH CBP/P300 WITHOUT OVERALLTITL 3 CONFORMATIONAL CHANGE.REF GENES CELLS V. 15 901 2010REFN ISSN 1356-9597PMID 20604809DOI 10.1111/J.1365-2443.2010.01427.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2l1i HLTF nmr structure of the hltf hiran domain -1.0Å AUTH D.NECULAI,I.BEZSONOVA,J.WEIGELT,C.BOUNTRA,A.EDWARDS,AUTH 2 C.ARROWSMITH,S.DHE-PAGANONTITL NMR STRUCTURE OF THE HLTF HIRAN DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l15 TEAD2 human tead2 transcriptional factor 2.0Å AUTH W.TIAN,J.YU,D.R.TOMCHICK,D.PAN,X.LUOTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE YAP-BINDINGTITL 2 DOMAIN OF HUMAN TEAD2.REF PROC.NATL.ACAD.SCI.USA V. 107 7293 2010REFN ISSN 0027-8424PMID 20368466DOI 10.1073/PNAS.1000293107 Variant Set Distributions Mapped Variants
General Structure Information 1xtj DDX39B structure of human uap56 in complex with adp 2.7Å AUTH H.SHI,O.CORDIN,C.M.MINDER,P.LINDER,R.-M.XUTITL CRYSTAL STRUCTURE OF THE HUMAN ATP-DEPENDENTTITL 2 SPLICING AND EXPORT FACTOR UAP56REF PROC.NATL.ACAD.SCI.USA V. 101 17628 2004REFN ISSN 0027-8424PMID 15585580DOI 10.1073/PNAS.0408172101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dsh IRF5 crystal structure of dimeric interferon regulatory factor 5 (irf-5) transactivation domain 2.0Å AUTH W.CHEN,S.S.LAM,H.SRINATH,Z.JIANG,J.J.CORREIA,C.A.SCHIFFER,AUTH 2 K.A.FITZGERALD,K.LIN,W.E.ROYERTITL INSIGHTS INTO INTERFERON REGULATORY FACTOR ACTIVATION FROMTITL 2 THE CRYSTAL STRUCTURE OF DIMERIC IRF5.REF NAT.STRUCT.MOL.BIOL. V. 15 1213 2008REFN ISSN 1545-9993PMID 18836453DOI 10.1038/NSMB.1496 Variant Set Distributions Mapped Variants
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]