Assessment of Structural Intolerance and Durability
General Structure Information 1alu IL6 human interleukin-6 1.9Å AUTH W.SOMERS,M.STAHL,J.S.SEEHRATITL 1.9 A CRYSTAL STRUCTURE OF INTERLEUKIN 6: IMPLICATIONS FOR ATITL 2 NOVEL MODE OF RECEPTOR DIMERIZATION AND SIGNALING.REF EMBO J. V. 16 989 1997REFN ISSN 0261-4189PMID 9118960DOI 10.1093/EMBOJ/16.5.989 Variant Set Distributions Mapped Variants
General Structure Information 2knc ITGB3 platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v5p IGF2 complex structure of human igf2r domains 11-13 bound to igf-ii 4.1Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,AUTH 2 R.J.GILBERT,G.VAN BOXEL,A.DENLEY,J.C.WALLACE,AUTH 3 A.B.HASSAN,B.E.FORBES,E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THETITL 2 IGF-II/IGF2R INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Mapped Variants
General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1e4j FCGR3B crystal structure of the soluble human fc-gamma receptor iii 2.5Å AUTH P.SONDERMANN,R.HUBER,V.OOSTHUIZEN,U.JACOBTITL THE 3.2-A CRYSTAL STRUCTURE OF THE HUMAN IGG1 FCTITL 2 FRAGMENT-FC GAMMARIII COMPLEX.REF NATURE V. 406 267 2000REFN ISSN 0028-0836PMID 10917521DOI 10.1038/35018508 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kq4 CUBN structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bkw ZFYVE9 crystal structure of the c-terminal region of human zfyve9 2.53Å AUTH E.WILLIAMSTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMAN ZFYVE9REF PH D THESIS 2013PUBL NULL: UNIVERSITY OF OXFORD (THESIS) Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2z7x TLR2 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4g8a TLR4 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]