Assessment of Structural Intolerance and Durability
General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]
General Structure Information 2knc ITGA2B platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Mapped Variants
General Structure Information 2v5o IGF2R structure of human igf2r domains 11-14 2.91Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,R.J.GILBERT,AUTH 2 G.VAN BOXEL,A.DENLEY,J.C.WALLACE,A.B.HASSAN,B.E.FORBES,AUTH 3 E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE IGF-II/IGF2RTITL 2 INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3gt8 EGFR crystal structure of the inactive egfr kinase domain in complex with amp-pnp 2.96Å AUTH N.JURA,N.F.ENDRES,K.ENGEL,S.DEINDL,R.DAS,AUTH 2 M.H.LAMERS,D.E.WEMMER,X.ZHANG,J.KURIYANTITL MECHANISM FOR ACTIVATION OF THE EGF RECEPTORTITL 2 CATALYTIC DOMAIN BY THE JUXTAMEMBRANE SEGMENT.REF CELL(CAMBRIDGE,MASS.) V. 137 1293 2009REFN ISSN 0092-8674PMID 19563760DOI 10.1016/J.CELL.2009.04.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]
General Structure Information 2jq3 APOC3 structure and dynamics of human apolipoprotein c-iii -1.0Å AUTH C.S.GANGABADAGE,J.ZDUNEK,M.TESSARI,S.NILSSON,AUTH 2 G.OLIVECRONA,S.S.WIJMENGATITL STRUCTURE AND DYNAMICS OF HUMAN APOLIPOPROTEIN CIIIREF J.BIOL.CHEM. V. 283 17416 2008REFN ISSN 0021-9258PMID 18408013DOI 10.1074/JBC.M800756200 Variant Set Distributions Mapped Variants
General Structure Information 3e7c NR3C1 glucocorticoid receptor lbd bound to gsk866 2.15Å AUTH K.P.MADAUSS,R.K.BLEDSOE,I.MCLAY,E.L.STEWART,I.J.UINGS,AUTH 2 G.WEINGARTEN,S.P.WILLIAMSTITL THE FIRST X-RAY CRYSTAL STRUCTURE OF THE GLUCOCORTICOIDTITL 2 RECEPTOR BOUND TO A NON-STEROIDAL AGONIST.REF BIOORG.MED.CHEM.LETT. V. 18 6097 2008REFN ISSN 0960-894XPMID 18952422DOI 10.1016/J.BMCL.2008.10.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hkf NCR2 the three dimensional structure of nk cell receptor nkp44, a triggering partner in natural cytotoxicity 2.2Å AUTH C.CANTONI,M.PONASSI,R.BIASSONI,R.CONTE,AUTH 2 A.SPALLAROSSA,A.MORETTA,L.MORETTA,M.BOLOGNESI,AUTH 3 D.BORDOTITL THE THREE-DIMENSIONAL STRUCTURE OF THE HUMAN NKTITL 2 CELL RECEPTOR NKP44, A TRIGGERING PARTNER INTITL 3 NATURAL CYTOTOXICITYREF STRUCTURE V. 11 725 2003REFN ISSN 0969-2126PMID 12791260DOI 10.1016/S0969-2126(03)00095-9 Variant […]