Assessment of Structural Intolerance and Durability
General Structure Information 3zjb TRAF4 the structure of the traf domain of human traf4 1.84Å AUTH A.ROUSSEAU,A.G.MCEWEN,P.POUSSIN-COURMONTAGNE,D.ROGNAN,AUTH 2 Y.NOMINE,M.-C.RIO,C.TOMASETTO,F.ALPYTITL TRAF4 IS A NOVEL PHOSPHOINOSITIDE-BINDING PROTEINTITL 2 MODULATING TIGHT JUNCTIONS AND FAVORING CELL MIGRATION.REF PLOS BIOL. V. 11 1726 2013REFN ISSN 1544-9173PMID 24311986DOI 10.1371/JOURNAL.PBIO.1001726 Variant Set Distributions Mapped Variants
General Structure Information 2kk0 ARID3A solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (nesg) target hr4394c -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE ARID DOMAIN OF HUMAN AT-RICHTITL 2 INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A: A HUMAN CANCERTITL 3 PROTEIN INTERACTION NETWORK TARGET.REF PROTEINS V. […]
General Structure Information 2heh KIF2C crystal structure of the kif2c motor domain (casp target) 2.15Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIF2C MOTOR DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2coa PRKD2 solution structure of the ph domain of protein kinase c, d2 type from human -1.0Å AUTH H.LI,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, D2 TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2h57 ARL6 crystal structure of human adp-ribosylation factor-like 6 2.0Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,J.LEW,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATIONTITL 2 FACTOR-LIKE 6 (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lj8 DUSP9 crystal structure of mkp-4 2.7Å AUTH D.G.JEONG,T.S.YOON,S.-K.JUNG,B.C.PARK,H.S.PARK,S.E.RYU,AUTH 2 S.J.KIMTITL EXPLORING BINDING SITES OTHER THAN THE CATALYTIC CORE IN THETITL 2 CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MKP-4REF ACTA CRYSTALLOGR.,SECT.D V. 67 25 2011REFN ISSN 0907-4449PMID 21206059DOI 10.1107/S0907444910042381 Variant Set Distributions Mapped Variants
General Structure Information 4n1d NODAL nodal/bmp2 chimera nb250 1.91Å AUTH L.ESQUIVIES,A.BLACKLER,M.PERAN,C.RODRIGUEZ-ESTEBAN,AUTH 2 J.C.IZPISUA BELMONTE,E.BOOKER,P.C.GRAY,C.AHN,W.KWIATKOWSKI,AUTH 3 S.CHOETITL DESIGNER NODAL/BMP2 CHIMERAS MIMIC NODAL SIGNALING, PROMOTETITL 2 CHONDROGENESIS, AND REVEAL A BMP2-LIKE STRUCTURE.REF J.BIOL.CHEM. V. 289 1788 2014REFN ISSN 0021-9258PMID 24311780DOI 10.1074/JBC.M113.529180 Variant Set Distributions Mapped Variants
General Structure Information 2ovj RACGAP1 the crystal structure of the human rac gtpase activating protein 1 (racgap1) mgcracgap. 1.49Å AUTH L.SHRESTHA,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,J.ELKINS,AUTH 2 C.JOHANSSON,F.VON DELFT,A.C.W.PIKE,N.BURGESS,A.TURNBULL,AUTH 3 J.DEBRECZENI,F.GORREC,C.UMEANO,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATINGTITL 2 PROTEIN 1 (RACGAP1) MGCRACGAP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ew3 SH3GL3 solution structure of the sh3 domain of human sh3gl3 -1.0Å AUTH Y.G.GAO,X.Z.YAN,H.Y.HUTITL STRUCTURAL BASIS FOR THE BINDING SPECIFICITIES OFTITL 2 HUNTINGTIN PROLINE-RICH REGION WITH SH3 AND WWTITL 3 DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uw4 UPF3B the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants