Assessment of Structural Intolerance and Durability
General Structure Information 4ic7 MAP2K5 crystal structure of the erk5 kinase domain in complex with an mkk5 binding fragment 2.6Å AUTH G.GLATZ,G.GOGL,A.ALEXA,A.REMENYITITL STRUCTURAL MECHANISM FOR THE SPECIFIC ASSEMBLY ANDTITL 2 ACTIVATION OF THE EXTRACELLULAR SIGNAL REGULATED KINASE 5TITL 3 (ERK5) MODULE.REF J.BIOL.CHEM. V. 288 8596 2013REFN ISSN 0021-9258PMID 23382384DOI 10.1074/JBC.M113.452235 Variant Set Distributions Mapped Variants
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants
General Structure Information 2ytu FLI1 solution structure of the sam_pnt-domain of the human friend leukemiaintegration 1 transcription factor -1.0Å AUTH A.K.GORONCY,M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,AUTH 2 T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HUMAN FRIEND LEUKEMIAINTEGRATION 1 TRANSCRIPTIONTITL 3 FACTORREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 1uv0 REG3A pancreatitis-associated protein 1 from human 1.78Å AUTH C.ABERGEL,S.CHENIVESSE,M.G.STINNAKRE,S.GUASCO,C.BRECHOT,AUTH 2 J.M.CLAVERIE,E.DEVINOY,L.CHRISTATITL CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC STUDY OFTITL 2 HIP/PAP, A HUMAN C-LECTIN OVEREXPRESSED IN PRIMARY LIVERTITL 3 CANCERS.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1487 1999REFN ISSN 0907-4449PMID 10417404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dh7 TIAL1 solution structure of the second rna binding domain in nucleolysin tiar -1.0Å AUTH T.IMAI,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA BINDINGTITL 2 DOMAIN IN NUCLEOLYSIN TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3vvw CALCOCO2 ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Mapped Variants
General Structure Information 3rl8 DLG1 crytal structure of hdlg1-pdz2 complexed with apc 2.2Å AUTH Z.ZHANG,H.LI,L.CHEN,X.LU,J.ZHANG,P.XU,K.LIN,G.WUTITL MOLECULAR BASIS FOR THE RECOGNITION OF ADENOMATOUS POLYPOSISTITL 2 COLI BY THE DISCS LARGE 1 PROTEIN.REF PLOS ONE V. 6 23507 2011REFN ESSN 1932-6203PMID 21858148DOI 10.1371/JOURNAL.PONE.0023507 Variant Set Distributions Mapped Variants
General Structure Information 2ct2 TRIM32 solution structure of the ring domain of the tripartite motif protein 32 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THETITL 2 TRIPARTITE MOTIF PROTEIN 32REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]