Assessment of Structural Intolerance and Durability
General Structure Information 2lb2 NEDD4L structure of the second domain of human nedd4l in complex with a phosphorylated ptpy motif derived from human smad3 -1.0Å AUTH E.ARAGON,N.GOERNER,A.I.ZAROMYTIDOU,Q.XI,A.ESCOBEDO,AUTH 2 J.MASSAGUE,M.J.MACIASTITL A SMAD ACTION TURNOVER SWITCH OPERATED BY WW DOMAIN READERSTITL 2 OF A PHOSPHOSERINE CODE.REF GENES DEV. V. 25 1275 2011REFN ISSN 0890-9369PMID 21685363DOI 10.1101/GAD.2060811 Variant […]
General Structure Information 4jxh CYTH2 complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5 1.47Å AUTH J.ROUHANA,F.HOH,S.ESTARAN,C.HENRIQUET,Y.BOUBLIK,A.KERKOUR,AUTH 2 R.TROUILLARD,J.MARTINEZ,M.PUGNIERE,A.PADILLA,A.CHAVANIEUTITL FRAGMENT-BASED IDENTIFICATION OF A LOCUS IN THE SEC7 DOMAINTITL 2 OF ARNO FOR THE DESIGN OF PROTEIN-PROTEIN INTERACTIONTITL 3 INHIBITORSREF J.MED.CHEM. V. 56 8497 2013REFN ISSN 0022-2623PMID 24112024DOI 10.1021/JM4009357 Variant Set […]
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4drb FANCM the crystal structure of fancm bound mhf complex 2.63Å AUTH Y.TAO,C.JIN,X.LI,S.QI,L.CHU,L.NIU,X.YAO,M.TENGTITL THE STRUCTURE OF THE FANCM-MHF COMPLEX REVEALS PHYSICALTITL 2 FEATURES FOR FUNCTIONAL ASSEMBLYREF NAT COMMUN V. 3 782 2012REFN ESSN 2041-1723PMID 22510687DOI 10.1038/NCOMMS1779 Variant Set Distributions Mapped Variants
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]
General Structure Information 4ndy APITD1 human mhf1-mhf2 dna complex 7.0Å AUTH Q.ZHAO,D.SARO,A.SACHPATZIDIS,T.R.SINGH,D.SCHLINGMAN,AUTH 2 X.F.ZHENG,A.MACK,M.S.TSAI,S.MOCHRIE,L.REGAN,A.R.MEETEI,AUTH 3 P.SUNG,Y.XIONGTITL THE MHF COMPLEX SENSES BRANCHED DNA BY BINDING A PAIR OFTITL 2 CROSSOVER DNA DUPLEXES.REF NAT COMMUN V. 5 2987 2014REFN ESSN 2041-1723PMID 24390579DOI 10.1038/NCOMMS3987 Variant Set Distributions Mapped Variants
General Structure Information 1y8p PDK3 crystal structure of the pdk3-l2 complex 2.63Å AUTH M.KATO,J.L.CHUANG,S.C.TSO,R.M.WYNN,D.T.CHUANGTITL CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE 3 BOUNDTITL 2 TO LIPOYL DOMAIN 2 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF EMBO J. V. 24 1763 2005REFN ISSN 0261-4189PMID 15861126DOI 10.1038/SJ.EMBOJ.7600663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]
General Structure Information 4dck SCN5A crystal structure of the c-terminus of voltage-gated sodium channel in complex with fgf13 and cam 2.2Å AUTH C.WANG,B.C.CHUNG,H.YAN,S.Y.LEE,G.S.PITTTITL CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF A NAV C-TERMINALTITL 2 DOMAIN, A FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR, ANDTITL 3 CALMODULIN.REF STRUCTURE V. 20 1167 2012REFN ISSN 0969-2126PMID 22705208DOI 10.1016/J.STR.2012.05.001 Variant Set […]