Assessment of Structural Intolerance and Durability
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wqz NLGN4X crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement 3.9Å AUTH I.P.FABRICHNY,P.LEONE,G.SULZENBACHER,D.COMOLETTI,M.T.MILLER,AUTH 2 P.TAYLOR,Y.BOURNE,P.MARCHOTTITL STRUCTURAL ANALYSIS OF THE SYNAPTIC PROTEIN NEUROLIGIN ANDTITL 2 ITS BETA-NEUREXIN COMPLEX: DETERMINANTS FOR FOLDING ANDTITL 3 CELL ADHESION.REF NEURON V. 56 979 2007REFN ISSN 0896-6273PMID 18093521DOI 10.1016/J.NEURON.2007.11.013 Variant Set Distributions Ripley’s […]
General Structure Information 3iec MARK2 helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates 2.2Å AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ebt KLF5 solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THREE TANDEM REPEATS OFTITL 2 ZF-C2H2 DOMAINS FROM HUMAN KRUPPEL-LIKE FACTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nbn NOTCH1 crystal structure of a dimer of notch transcription complex trimers on hes1 dna 3.45Å AUTH K.L.ARNETT,M.HASS,D.G.MCARTHUR,M.X.ILAGAN,J.C.ASTER,R.KOPAN,AUTH 2 S.C.BLACKLOWTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO COOPERATIVETITL 2 ASSEMBLY OF DIMERIC NOTCH TRANSCRIPTION COMPLEXES.REF NAT.STRUCT.MOL.BIOL. V. 17 1312 2010REFN ISSN 1545-9993PMID 20972443DOI 10.1038/NSMB.1938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]