Assessment of Structural Intolerance and Durability
General Structure Information 2rlo AGAP2 split ph domain of pi3-kinase enhancer -1.0Å AUTH J.YAN,W.WEN,L.N.CHAN,M.ZHANGTITL SPLIT PLECKSTRIN HOMOLOGY DOMAIN-MEDIATEDTITL 2 CYTOPLASMIC-NUCLEAR LOCALIZATION OF PI3-KINASETITL 3 ENHANCER GTPASEREF J.MOL.BIOL. V. 378 425 2008REFN ISSN 0022-2836PMID 18371979DOI 10.1016/J.JMB.2008.02.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3oln UHRF2 crystal structure of the sra domain of e3 ubiquitin-protein ligase uhrf2 2.3Å AUTH J.R.WALKER,S.XUE,G.V.AVVAKUMOV,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE SET AND RING ASSOCIATED (SRA) DOMAIN OF HUMANTITL 2 UBIQUITIN-LIKE CONTAINING PHD AND RING FINGER DOMAINS 2TITL 3 (UHRF2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2v66 NDEL1 crystal structure of the coiled-coil domain of ndel1 (a.a. 58 to 169)c 2.1Å AUTH U.DEREWENDA,C.TARRICONE,W.C.CHOI,D.R.COOPER,S.LUKASIK,AUTH 2 F.PERRINA,A.TRIPATHY,M.H.KIM,D.S.CAFISO,A.MUSACCHIO,AUTH 3 Z.S.DEREWENDATITL THE STRUCTURE OF THE COILED-COIL DOMAIN OF NDEL1 AND THETITL 2 BASIS OF ITS INTERACTION WITH LIS1, THE CAUSAL PROTEIN OFTITL 3 MILLER-DIEKER LISSENCEPHALY.REF STRUCTURE V. 15 1467 2007REFN ISSN 0969-2126PMID […]
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zv2 CAMKK2 crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, camkk2 kinase domain in complex with sto-609 2.4Å AUTH M.KUKIMOTO-NIINO,S.YOSHIKAWA,T.TAKAGI,N.OHSAWA,Y.TOMABECHI,AUTH 2 T.TERADA,M.SHIROUZU,A.SUZUKI,S.LEE,T.YAMAUCHI,M.OKADA-IWABU,AUTH 3 M.IWABU,T.KADOWAKI,Y.MINOKOSHI,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT PROTEINTITL 2 KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609REF J.BIOL.CHEM. V. 286 22570 2011REFN ISSN 0021-9258PMID 21504895DOI 10.1074/JBC.M111.251710 Variant Set […]
General Structure Information 1wbp SRPK1 srpk1 bound to 9mer docking motif peptide 2.4Å AUTH J.C.NGO,S.CHAKRABARTI,J.-H.DING,A.VELAZQUEZ-DONES,AUTH 2 B.NOLEN,B.E.AUBOL,J.A.ADAMS,X.-D.FU,G.GHOSHTITL INTERPLAY BETWEEN SRPK AND CLK/STY KINASES INTITL 2 PHOSPHORYLATION OF THE SPLICING FACTOR ASF/SF2 ISTITL 3 REGULATED BY A DOCKING MOTIF IN ASF/SF2REF MOL.CELL V. 20 77 2005REFN ISSN 1097-2765PMID 16209947DOI 10.1016/J.MOLCEL.2005.08.025 Variant Set Distributions Mapped Variants
General Structure Information 2hw6 MKNK1 crystal structure of mnk1 catalytic domain 2.5Å AUTH R.JAUCH,M.K.CHO,C.NETTER,K.SCHREITER,B.AICHER,AUTH 2 M.ZWECKSTETTER,M.C.WAHLTITL MITOGEN-ACTIVATED PROTEIN KINASES INTERACTING KINASES ARETITL 2 AUTOINHIBITED BY A REPROGRAMMED ACTIVATION SEGMENT.REF EMBO J. V. 25 4020 2006REFN ISSN 0261-4189PMID 16917500DOI 10.1038/SJ.EMBOJ.7601285 Variant Set Distributions Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xnk TOPBP1 structure and function of the rad9-binding region of the dna damage checkpoint adaptor topbp1 2.6Å AUTH M.RAPPAS,A.W.OLIVER,L.H.PEARLTITL STRUCTURE AND FUNCTION OF THE RAD9-BINDING REGION OF THETITL 2 DNA-DAMAGE CHECKPOINT ADAPTOR TOPBP1.REF NUCLEIC ACIDS RES. V. 39 313 2011REFN ISSN 0305-1048PMID 20724438DOI 10.1093/NAR/GKQ743 Variant Set Distributions Mapped Variants
General Structure Information 2vge PPP1R13L crystal structure of the c-terminal region of human iaspp 2.1Å AUTH R.A.ROBINSON,X.LU,E.Y.JONES,C.SIEBOLDTITL BIOCHEMICAL AND STRUCTURAL STUDIES OF ASPPTITL 2 PROTEINS REVEAL DIFFERENTIAL BINDING TO P53, P63TITL 3 AND P73REF STRUCTURE V. 16 259 2008REFN ISSN 0969-2126PMID 18275817DOI 10.1016/J.STR.2007.11.012 Variant Set Distributions Mapped Variants