Assessment of Structural Intolerance and Durability
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3ex7 MAGOH the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kqs SUMO1 phosphorylation of sumo-interacting motif by ck2 enhances daxx sumo binding activity -1.0Å AUTH C.C.CHANG,M.T.NAIK,Y.S.HUANG,J.C.JENG,P.H.LIAO,H.Y.KUO,AUTH 2 C.C.HO,Y.L.HSIEH,C.H.LIN,N.J.HUANG,N.M.NAIK,C.C.KUNG,AUTH 3 S.Y.LIN,R.H.CHEN,K.S.CHANG,T.H.HUANG,H.M.SHIHTITL STRUCTURAL AND FUNCTIONAL ROLES OF DAXX SIM PHOSPHORYLATIONTITL 2 IN SUMO PARALOG-SELECTIVE BINDING AND APOPTOSIS MODULATION.REF MOL.CELL V. 42 62 2011REFN ISSN 1097-2765PMID 21474068DOI 10.1016/J.MOLCEL.2011.02.022 Variant Set Distributions Mapped Variants
General Structure Information 2vom TPI1 structural basis of human triosephosphate isomerase deficiency. mutation e104d and correlation to solvent perturbation. 1.85Å AUTH C.RODRIGUEZ-ALMAZAN,R.ARREOLA-ALEMON,AUTH 2 D.RODRIGUEZ-LARREA,B.AGUIRRE-LOPEZ,AUTH 3 M.T.DE GOMEZ-PUYOU,R.PEREZ-MONTFORT,M.COSTAS,AUTH 4 A.GOMEZ-PUYOU,A.TORRES-LARIOSTITL STRUCTURAL BASIS OF HUMAN TRIOSEPHOSPHATETITL 2 ISOMERASE DEFICIENCY: MUTATION E104D IS RELATED TOTITL 3 ALTERATIONS OF A CONSERVED WATER NETWORK AT THETITL 4 DIMER INTERFACE.REF J.BIOL.CHEM. […]
General Structure Information 3d4j MVD crystal structure of human mevalonate diphosphate decarboxylase 2.4Å AUTH N.E.VOYNOVA,Z.FU,K.P.BATTAILE,T.J.HERDENDORF,AUTH 2 J.J.KIM,H.M.MIZIORKOTITL HUMAN MEVALONATE DIPHOSPHATE DECARBOXYLASE:TITL 2 CHARACTERIZATION, INVESTIGATION OF THE MEVALONATETITL 3 DIPHOSPHATE BINDING SITE, AND CRYSTAL STRUCTURE.REF ARCH.BIOCHEM.BIOPHYS. V. 480 58 2008REFN ISSN 0003-9861PMID 18823933DOI 10.1016/J.ABB.2008.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3law RAB7A structure of gtp-bound l129f mutant rab7 2.8Å AUTH B.A.MCCRAY,E.SKORDALAKES,J.P.TAYLORTITL DISEASE MUTATIONS IN RAB7 RESULT IN UNREGULATED NUCLEOTIDETITL 2 EXCHANGE AND INAPPROPRIATE ACTIVATION.REF HUM.MOL.GENET. V. 19 1033 2010REFN ISSN 0964-6906PMID 20028791DOI 10.1093/HMG/DDP567 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ka4 STAT2 nmr structure of the cbp-taz1/stat2-tad complex -1.0Å AUTH J.M.WOJCIAK,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR RECRUITMENT OF CBP/P300TITL 2 COACTIVATORS BY STAT1 AND STAT2 TRANSACTIVATIONTITL 3 DOMAINSREF EMBO J. V. 28 948 2009REFN ISSN 0261-4189PMID 19214187DOI 10.1038/EMBOJ.2009.30 Variant Set Distributions Mapped Variants
General Structure Information 2kg1 HNRNPF structure of the third qrrm domain of hnrnp f in complex with a agggau g-tract rna -1.0Å AUTH C.DOMINGUEZ,J.F.FISETTE,B.CHABOT,F.H.ALLAINTITL STRUCTURAL BASIS OF G-TRACT RECOGNITION AND ENCAGING BYTITL 2 HNRNP F QUASI-RRMS.REF NAT.STRUCT.MOL.BIOL. V. 17 853 2010REFN ISSN 1545-9993PMID 20526337DOI 10.1038/NSMB.1814 Variant Set Distributions Mapped Variants
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 3l2p LIG3 human dna ligase iii recognizes dna ends by dynamic switching between two dna bound states 3.0Å AUTH E.COTNER-GOHARA,I.K.KIM,M.HAMMEL,J.A.TAINER,A.E.TOMKINSON,AUTH 2 T.ELLENBERGERTITL HUMAN DNA LIGASE III RECOGNIZES DNA ENDS BY DYNAMICTITL 2 SWITCHING BETWEEN TWO DNA-BOUND STATES.REF BIOCHEMISTRY V. 49 6165 2010REFN ISSN 0006-2960PMID 20518483DOI 10.1021/BI100503W Variant Set Distributions Ripley’s K Analysis […]