Assessment of Structural Intolerance and Durability
General Structure Information 3i4r NUP107 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Mapped Variants
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants
General Structure Information 3g73 FOXM1 structure of the foxm1 dna binding 2.21Å AUTH D.R.LITTLER,M.ALVAREZ-FERNANDEZ,A.STEIN,R.G.HIBBERT,AUTH 2 T.HEIDEBRECHT,P.ALOY,R.H.MEDEMA,A.PERRAKISTITL STRUCTURE OF THE FOXM1 DNA-RECOGNITION DOMAIN BOUND TO ATITL 2 PROMOTER SEQUENCEREF NUCLEIC ACIDS RES. 2010REFN ESSN 1362-4962PMID 20360045DOI 10.1093/NAR/GKQ194 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants